Mononuclear cell trafficking and plasma protein extravasation into the CNS during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice

1991 ◽  
Vol 104 (1) ◽  
pp. 9-12 ◽  
Author(s):  
C. Butter ◽  
D. Baker ◽  
J.K. O'Neill ◽  
J.L. Turk
Keyword(s):  
Mononuclear Cell ◽  
Plasma Protein ◽  
Experimental Allergic Encephalomyelitis ◽  
Cell Trafficking ◽  
Allergic Encephalomyelitis ◽  
Protein Extravasation ◽  
Plasma Protein Extravasation ◽  
Experimental Allergic

Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat

2001 ◽  
Vol 7 (2) ◽  
pp. 101-104 ◽  
Author(s):  
Roberto Di Marco ◽  
Gaetano Puglisi ◽  
Gianpaolo Papaccio ◽  
Alessandra Nicoletti ◽  
Francesco Patti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mononuclear Cell ◽  
Experimental Allergic Encephalomyelitis ◽  
Prophylactic Treatment ◽  
Lewis Rat ◽  
Mononuclear Cell Infiltration ◽  
Allergic Encephalomyelitis ◽  
Delayed Onset ◽  
Experimental Allergic ◽  
Inflammatory Effect

We have evaluated the effect of the immunosuppressant sodium fusidate (fusidin) on the course of acute monophasic experimental encephalomyelitis (EAE) in male Lewis rats. Prophylactic treatment with fusidin, 80 or 120 mg/kg bd wt., markedly ameliorated the course of the disease in rats immunized with myelin basic proteins in complete Freund's adjuvant, entailing delayed onset of symptoms, lower clinical scores and more rapid recovery than PBS-treated control rats. The fusidin-treated, immunized rats exhibited milder mononuclear cell infiltration of brains and spinal cords than control animals. These data provide further evidence for the anti-inflammatory effect of fusidin and suggest that this drug may be valuable for the treatment of human multiple sclerosis.

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