Acetylcholine-induced production of platelet-activating factor by human fetal brain cells in culture

1990 ◽  
Vol 27 (4) ◽  
pp. 706-711 ◽  
Author(s):  
V. Sogos ◽  
F. Bussolino ◽  
E. Pilia ◽  
S. Torelli ◽  
F. Gremo
Keyword(s):  
Platelet Activating Factor ◽  
Fetal Brain ◽  
Brain Cells ◽  
Human Fetal Brain ◽  
Cells In Culture

scholarly journals Separating chemotherapy-related developmental neurotoxicity from cytotoxicity in monolayer and neurosphere cultures of human fetal brain cells

2016 ◽  
Vol 37 ◽  
pp. 88-96 ◽  
Author(s):  
Delyan P. Ivanov ◽  
Abdal-jabbar Al-Rubai ◽  
Anna M. Grabowska ◽  
Margaret K. Pratten
Keyword(s):  
Fetal Brain ◽  
Developmental Neurotoxicity ◽  
Brain Cells ◽  
Human Fetal Brain

Dexamethasone-Induced Accumulation of Neuropeptide-Y by Aggregating Fetal Brain Cells in Culture: A Process Dependent on the Developmental Age of the Aggregates*

Endocrinology ◽  
1991 ◽  
Vol 129 (2) ◽  
pp. 931-938 ◽  
Author(s):  
AYALLA BARNEA ◽  
GLORIA CHO ◽  
ASGHAR HAJIBEIGI ◽  
M. CECILIA AGUILA ◽  
PAOLO MAGNI
Keyword(s):  
Neuropeptide Y ◽  
Fetal Brain ◽  
Brain Cells ◽  
Cells In Culture ◽  
Developmental Age

Repair of O6-methylguanine in human fetal brain and skin cells in culture

1984 ◽  
Vol 5 (12) ◽  
pp. 1657-1661 ◽  
Author(s):  
Steven M. D'Ambrosio ◽  
Gulzar Wani ◽  
Mervyn Samuel ◽  
Ruth E. Gibson-D'Ambrosio
Keyword(s):  
Fetal Brain ◽  
Human Fetal Brain ◽  
Skin Cells ◽  
Cells In Culture

scholarly journals Nodosome inhibition as a novel broad-spectrum antiviral strategy against arboviruses and SARS-CoV-2

2020 ◽  
Author(s):  
Daniel Limonta ◽  
Lovely Dyna-Dagman ◽  
William Branton ◽  
Tadashi Makio ◽  
Richard W. Wozniak ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Small Molecules ◽  
Broad Spectrum ◽  
Present Report ◽  
Fetal Brain ◽  
Interferon Response ◽  
Brain Cells ◽  
Human Fetal Brain ◽  
Block Formation ◽  
Oligomerization Domain

ABSTRACTIn the present report, we describe two small molecules with broad-spectrum antiviral activity. These drugs block formation of the nodosome. The studies were prompted by the observation that infection of human fetal brain cells with Zika virus (ZIKV) induces expression of nucleotide-binding oligomerization domain-containing protein 2 (NOD2), a host factor that was found to promote ZIKV replication and spread. A drug that targets NOD2 was shown to have potent broad-spectrum antiviral activity against other flaviviruses, alphaviruses and SARS-CoV-2, the causative agent of COVID-19. Another drug that inhibits the receptor-interacting serine/threonine-protein kinase 2 (RIPK2) which functions downstream of NOD2, also decreased replication of these pathogenic RNA viruses. The broad-spectrum action of nodosome targeting drugs is mediated, at least in part, by enhancement of the interferon response. Together, these results suggest that further preclinical investigation of nodosome inhibitors as potential broad-spectrum antivirals is warranted.

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