Myricetin attenuates lipopolysaccharide-stimulated activation of mouse bone marrow-derived dendritic cells through suppression of IKK/NF-κB and MAPK signalling pathways

2012 ◽  
Vol 93 (1) ◽  
pp. 76-84 ◽  
Author(s):  
Ru-Huei Fu ◽  
Shih-Ping Liu ◽  
Ching-Liang Chu ◽  
Ya-Hsien Lin ◽  
Yu-Chen Ho ◽  
...  
2010 ◽  
Vol 135 ◽  
pp. S32
Author(s):  
Patricia Taylor ◽  
Gary Koski ◽  
Erin Bailey ◽  
Daniel Zimmerman ◽  
Ken S. Rosenthal

2020 ◽  
Vol 132 ◽  
pp. 563-573
Author(s):  
Qian Feng ◽  
Lingxia Li ◽  
Guoyu Du ◽  
Yongsheng Liu ◽  
Xiangtao Liu ◽  
...  

Author(s):  
Yifei Dong ◽  
Arif A. Arif ◽  
Grace F. T. Poon ◽  
Blair Hardman ◽  
Manisha Dosanjh ◽  
...  

2005 ◽  
Vol 73 (1) ◽  
pp. 413-421 ◽  
Author(s):  
Kenneth C. Bagley ◽  
Sayed F. Abdelwahab ◽  
Robert G. Tuskan ◽  
George K. Lewis

ABSTRACT Pasteurella multocida toxin (PMT) is a potent mitogen for fibroblasts and osteoblastic cells. PMT activates phospholipase C-β through Gqα, and the activation of this pathway is responsible for its mitogenic activity. Here, we investigated the effects of PMT on human monocyte-derived dendritic cells (MDDC) in vitro and show a novel activity for PMT. In this regard, PMT activates MDDC to mature in a dose-dependent manner through the activation of phospholipase C and subsequent mobilization of calcium. This activation was accompanied by enhanced stimulation of naïve alloreactive T cells and dominant inhibition of interleukin-12 production in the presence of saturating concentrations of lipopolysaccharide. Surprisingly, although PMT mimics the activating effects of cholera toxin on human MDDC and mouse bone marrow-derived dendritic cells, we found that PMT is not a mucosal adjuvant and that it suppresses the adjuvant effects of cholera toxin in mice. Together, these results indicate discordant effects for PMT in vitro compared to those in vivo.


2014 ◽  
Vol 69 ◽  
pp. 388-392 ◽  
Author(s):  
Jingjuan Meng ◽  
Yan Cao ◽  
Yiming Meng ◽  
Hong Luo ◽  
Xinghua Gao ◽  
...  

Stem Cells ◽  
1997 ◽  
Vol 15 (2) ◽  
pp. 144-153 ◽  
Author(s):  
Yasunori Yamaguchi ◽  
Haruhiko Tsumura ◽  
Mitsuru Miwa ◽  
Kayo Inaba

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