scholarly journals A Pareto‐based beam orientation optimization method for spot scanning intensity‐modulated proton therapy

2020 ◽  
Vol 47 (5) ◽  
pp. 2049-2060
Author(s):  
Hisham Kamal Sayed ◽  
M. G. Herman ◽  
C. J. Beltran
Keyword(s):  
Proton Therapy ◽  
Optimization Method ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Spot Scanning ◽  
Beam Orientation Optimization ◽  
Beam Orientation ◽  
Orientation Optimization

scholarly journals Robust beam orientation optimization for intensity‐modulated proton therapy

2019 ◽  
Vol 46 (8) ◽  
pp. 3356-3370 ◽  
Author(s):  
Wenbo Gu ◽  
Ryan Neph ◽  
Dan Ruan ◽  
Wei Zou ◽  
Lei Dong ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Beam Orientation Optimization ◽  
Beam Orientation ◽  
Orientation Optimization

scholarly journals Fraction‐variant beam orientation optimization for intensity‐modulated proton therapy

2020 ◽  
Vol 47 (9) ◽  
pp. 3826-3834
Author(s):  
Wenbo Gu ◽  
Daniel O'Connor ◽  
Dan Ruan ◽  
Wei Zou ◽  
Lei Dong ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Beam Orientation Optimization ◽  
Beam Orientation ◽  
Orientation Optimization

scholarly journals Integrated beam orientation and scanning-spot optimization in intensity-modulated proton therapy for brain and unilateral head and neck tumors

2018 ◽  
Vol 45 (4) ◽  
pp. 1338-1350 ◽  
Author(s):  
Wenbo Gu ◽  
Daniel O'Connor ◽  
Dan Nguyen ◽  
Victoria Y. Yu ◽  
Dan Ruan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Proton Therapy ◽  
Head And Neck Tumors ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Neck Tumors ◽  
Beam Orientation

scholarly journals Feasibility study: Spot-scanning Proton Arc therapy (SPArc) for left-sided breast irradiation

2020 ◽  
Author(s):  
Sheng Chang ◽  
Gang Liu ◽  
Lewei Zhao ◽  
Joshua T Dilworth ◽  
Weili Zheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Proton Therapy ◽  
Normal Tissue ◽  
Breast Irradiation ◽  
Ipsilateral Lung ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Spot Scanning ◽  
Proton Treatment ◽  
Beam Delivery

Abstract Background This study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning Proton Arc (SPArc) therapy for left-sided breast cancer irradiation to further reduce radiation dose to healthy tissue and mitigate the probability of normal tissue complications compared to conventional Intensity Modulated Proton Therapy(IMPT). Methods Eight patients diagnosed with left-sided breast cancer and treated with breast-preserving surgery followed by whole breast irradiation without regional nodal irradiation were included in this retrospective planning. Two proton treatment plans were generated for each patient: vertical intensity-modulated proton therapy used for clinical treatment (vIMPT, gantry angle 10°-30°) and SPArc for comparison purpose. Both SPArc and vIMPT plans were optimized using the robust optimization of ± 3.5% range and 5 mm setup uncertainties. Root-mean-square deviation dose (RMSD) volume histograms were used for plan robustness evaluation. All dosimetric results were evaluated based on dose-volume histograms (DVH), and the interplay effect was evaluated based on the accumulation of single-fraction 4D dynamic dose on CT50. The treatment beam delivery time was simulated based on a gantry rotation with energy-layer-switching-time (ELST) from 0.2 to 5 s. Results The average D1 to the heart and LAD were reduced to 53.63 cGy and 82.25 cGy compared with vIMPT 110.38 cGy (p = 0.001) and 170.38 cGy (p = 0.001), respectively. The average V5Gy and V20Gy of ipsilateral lung was reduced to 16.77% and 3.07% compared to vIMPT 25.56% (p = 0.001) and 4.68% (p = 0.003). Skin3mm mean and maximum dose was reduced to 3999.38 cGy and 4395.63 cGy compared to vIMPT 4104.25 cGy (p = 0.039) and 4411.63 cGy (p = 0.043), respectively. A significant relative risk reduction (RNTCP = NTCPSPArc / NTCPvIMPT) for organs at risk (OARs) was obtained with SPArc ranging from 0.61 to 0.86 depending on the clinical endpoint. The RMSD Volume Histogram(RVH) analysis shows SPArc provided better plan robustness in OARs sparing, including the heart, LAD, ipsilateral lung, and skin. The average estimated treatment beam delivery times were comparable to vIMPT plans when the ELST is about 0.5 s. Conclusion SPArc technique can further reduce dose delivered to OARs and the probability of normal tissue complications in patients treated for left-sided breast cancer.

scholarly journals Feasibility study: Spot-scanning Proton Arc therapy (SPArc) for left-sided whole breast radiotherapy

2020 ◽  
Author(s):  
Sheng Chang ◽  
Gang Liu ◽  
Lewei Zhao ◽  
Joshua T Dilworth ◽  
Weili Zheng ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Normal Tissue ◽  
Breast Radiotherapy ◽  
Ipsilateral Lung ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Spot Scanning ◽  
Whole Breast Radiotherapy ◽  
Proton Treatment ◽  
Beam Delivery

Abstract Background : This study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning Proton Arc (SPArc) therapy for left-sided whole breast radiotherapy (WBRT) to further reduce radiation dose to healthy tissue and mitigate the probability of normal tissue complications compared to conventional Intensity Modulated Proton Therapy (IMPT). Methods : Eight patients diagnosed with left-sided breast cancer and treated with breast-preserving surgery followed by whole breast irradiation without regional nodal irradiation were included in this retrospective planning. Two proton treatment plans were generated for each patient: vertical intensity-modulated proton therapy used for clinical treatment (vIMPT, gantry angle 10°-30°) and SPArc for comparison purpose. Both SPArc and vIMPT plans were optimized using the robust optimization of ±3.5% range and 5mm setup uncertainties. Root-mean-square deviation dose (RMSD) volume histogram s were used for plan robustness evaluation. All dosimetric results were evaluated based on dose-volume histograms (DVH), and the interplay effect was evaluated based on the accumulation of single-fraction 4D dynamic dose on CT50. The treatment beam delivery time was simulated based on a gantry rotation with energy-layer-switching-time (ELST) from 0.2 to 5s. Results: The average D1 to the heart and LAD were reduced to 53.63cGy and 82.25cGy compared with vIMPT 110.38cGy (p = 0.001) and 170.38cGy (p = 0.001), respectively. The average V5Gy and V20Gy of ipsilateral lung was reduced to 16.77% and 3.07% compared to vIMPT 25.56% (p = 0.001) and 4.68% (p = 0.003). Skin3mm mean and maximum dose were reduced to 3999.38cGy and 4395.63cGy compared to vIMPT 4104.25cGy (p=0.039) and 4411.63cGy (p=0.043), respectively. A significant relative risk reduction (RNTCP = NTCP SPArc / NTCP vIMPT ) for organs at risk (OARs) was obtained with SPArc ranging from 0.61 to 0.86 depending on the clinical endpoint. The RMSD Volume Histogram (RVH) analysis shows SPArc provided better plan robustness in OARs sparing, including the heart, LAD, ipsilateral lung, and skin. The average estimated treatment beam delivery times were comparable to vIMPT plans when the ELST is about 0.5s. Conclusion: SPArc technique can further reduce dose delivered to OARs and the probability of normal tissue complications in patient treated for left-sided WBRT.

Sign in / Sign up

Export Citation Format

Share Document