Economic assessment of maternal serum screening for Down's syndrome using human chorionic gonadotropin

1993 ◽  
Vol 13 (4) ◽  
pp. 281-292 ◽  
Author(s):  
V. Seror ◽  
F. Muller ◽  
J. P. Moatti ◽  
C. Le Gales ◽  
A. Boue
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Economic Assessment ◽  
Maternal Serum ◽  
Maternal Serum Screening ◽  
Serum Screening

Free β-Chorionic Gonadotropin: A Cross-Reactivity Study of Two Immunometric Assays Used in Prenatal Maternal Serum Screening for Down's Syndrome

1993 ◽  
Vol 30 (1) ◽  
pp. 94-98 ◽  
Author(s):  
James N Macri ◽  
Kevin Spencer ◽  
Robert W Anderson ◽  
Edward J Cook
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Detection Efficiency ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Cross Reactivity ◽  
Maternal Serum ◽  
Glycoprotein Hormones ◽  
Maternal Serum Screening ◽  
Reactivity Study

We have evaluated the cross-reactivity characteristics of two distinct immunometric assays for the measurement of free β-human chorionic gonadotropin (free β). These maternal serum assays have been used in the initial studies which evaluated free β as a marker in the prenatal detection of Down's syndrome. It has been suggested that free β assays are subject to substantial potential for cross-reactivity. To confirm that free β was the analyte responsible for enhanced detection efficiency both non-competitive and competitive cross-reactivity evaluations were undertaken. These studies demonstrated acceptably small cross-reactivity to other glycoprotein hormones or their β components. We conclude that properly designed free β assays will provide specific analyte measurement and improved detection efficiency in Down's syndrome screening.

Maternal serum screening for Down's syndrome

Public Health ◽  
1997 ◽  
Vol 111 (6) ◽  
pp. 383-385
Author(s):  
S Fairgrieve ◽  
D Magnay ◽  
I White ◽  
J Burn
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Maternal Serum ◽  
Maternal Serum Screening ◽  
Serum Screening
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