Templated chemistry for bioorganic synthesis and chemical biology

Oliver Seitz

doi:10.1002/psc.3198

Templated chemistry for bioorganic synthesis and chemical biology

Journal of Peptide Science ◽

10.1002/psc.3198 ◽

2019 ◽

Vol 25 (7) ◽

Cited By ~ 5

Author(s):

Oliver Seitz

Keyword(s):

Chemical Biology ◽

Bioorganic Synthesis

Chemical Biology of Glycoproteins

10.1039/9781782623823 ◽

2017 ◽

Cited By ~ 4

Keyword(s):

Chemical Biology

The Chemical Biology of Sulfur

10.1039/9781839161841 ◽

2020 ◽

Keyword(s):

Chemical Biology

The Chemical Biology of Phosphorus

10.1039/9781839162312 ◽

2020 ◽

Keyword(s):

Chemical Biology

Correction: Graduate Education in Chemical Biology at the University of Michigan

ACS Chemical Biology ◽

10.1021/cb600416x ◽

2006 ◽

Vol 1 (9) ◽

pp. 601

Author(s):

Tonia J. Buchholz ◽

Bruce Palfey ◽

Anna K. Mapp ◽

Gary D. Glick

Keyword(s):

Graduate Education ◽

Chemical Biology ◽

University Of Michigan ◽

The University

ACS Chemical Biology

10.1021/issn.1554-8929 ◽

2008 ◽

Keyword(s):

Chemical Biology

Chemical biology: A new twist in Alzheimer's disease

Nature China ◽

10.1038/nchina.2010.107 ◽

2010 ◽

Author(s):

Anne Pichon

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Chemical Biology

Chemical biology: A natural painkiller

Nature China ◽

10.1038/nchina.2014.3 ◽

2014 ◽

Author(s):

Felix Cheung

Keyword(s):

Chemical Biology

Chemical biology: Radical transformation

Nature China ◽

10.1038/nchina.2011.9 ◽

2011 ◽

Author(s):

Felix Cheung

Keyword(s):

Chemical Biology ◽

Radical Transformation

Chemical biology: On neutral ground

Nature China ◽

10.1038/nchina.2009.27 ◽

2009 ◽

Author(s):

Felix Cheung

Keyword(s):

Chemical Biology ◽

Neutral Ground

Selective Functionalization at N2-Position of Guanine in Oligonucleotides via Reductive Amination

10.26434/chemrxiv.12511661.v1 ◽

2020 ◽

Author(s):

Bapurao Bhoge ◽

Ishu Saraogi

Keyword(s):

Organic Chemistry ◽

Chemical Biology ◽

Reductive Amination ◽

The Other ◽

Dna Oligomers ◽

Site Specific ◽

Wide Applicability ◽

Dna Oligonucleotides ◽

Selective Functionalization

Chemo- and site-specific modifications in oligonucleotides have wide applicability as mechanistic probes in chemical biology. Here we have employed a classical reaction in organic chemistry, reductive amination, to selectively functionalize the N<sup>2</sup>-amine of guanine/2’-deoxyguanine monophosphate. This method specifically modifies guanine in several tested DNA oligonucleotides, while leaving the other bases unaffected. Using this approach, we have successfully incorporated desired handles chemoselectively into DNA oligomers.