Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic
            Physiologically‐Based Pharmacokinetic
            Model

Interaction Studies ◽

Physiologically Based ◽

Drug Drug Interaction ◽

Clinical Drug

Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.01.007 ◽

2017 ◽

Vol 106 (5) ◽

pp. 1439-1451 ◽

Cited By ~ 11

Author(s):

Wen Lin ◽

Tao Ji ◽

Heidi Einolf ◽

Surya Ayalasomayajula ◽

Tsu-Han Lin ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Model ◽

Physiologically Based ◽

Assessment of drug–drug interaction and optimization in capecitabine and irinotecan combination regimen using a physiologically based pharmacokinetic model

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2021.12.021 ◽

2021 ◽

Author(s):

Shuhei Sakai ◽

Shinji Kobuchi ◽

Yukako Ito ◽

Toshiyuki Sakaeda

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Model ◽

Combination Regimen ◽

Physiologically Based ◽

Quantitative prediction of the extent of drug–drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes

Xenobiotica ◽

10.1080/00498254.2017.1370744 ◽

2017 ◽

Vol 48 (8) ◽

pp. 770-780 ◽

Cited By ~ 1

Author(s):

Shinji Iwasaki ◽

Hideki Hirabayashi ◽

Nobuyuki Amano

Keyword(s):

Drug Interaction ◽

Drug Metabolism ◽

Pharmacokinetic Model ◽

Quantitative Prediction ◽

Physiologically Based ◽

Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz

In Silico Pharmacology ◽

10.1186/2193-9616-1-4 ◽

2013 ◽

Vol 1 (1) ◽

Cited By ~ 20

Author(s):

Marco Siccardi ◽

Adeniyi Olagunju ◽

Kay Seden ◽

Farid Ebrahimjee ◽

Steve Rannard ◽

...

Keyword(s):

Drug Interaction ◽

Dose Adjustment ◽

Pharmacokinetic Model ◽

Physiologically Based ◽

Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug-drug interaction potential of CYP3A4 substrates

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2122 ◽

2018 ◽

Vol 39 (3) ◽

pp. 152-163 ◽

Cited By ~ 6

Author(s):

Ken-ichi Umehara ◽

Felix Huth ◽

Christina S. Won ◽

Tycho Heimbach ◽

Handan He

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Model ◽

Physiologically Based ◽

Pharmacokinetic Drug–Drug Interaction of Apalutamide, Part 2: Investigating Interaction Potential Using a Physiologically Based Pharmacokinetic Model

Clinical Pharmacokinetics ◽

10.1007/s40262-020-00881-3 ◽

2020 ◽

Vol 59 (9) ◽

pp. 1149-1160 ◽

Cited By ~ 1

Author(s):

An Van den Bergh ◽

Jan Snoeys ◽

Loeckie De Zwart ◽

Peter Ward ◽

Angela Lopez-Gitlitz ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Model ◽

Physiologically Based ◽

Drug Drug Interaction ◽

Pharmacokinetic Drug

Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug–Drug Interaction Prediction

Clinical Pharmacokinetics ◽

10.1007/s40262-015-0352-5 ◽

2015 ◽

Vol 55 (6) ◽

pp. 735-749 ◽

Cited By ~ 12

Author(s):

Yuan Chen ◽

Fang Ma ◽

Tong Lu ◽

Nageshwar Budha ◽

Jin Yan Jin ◽

...

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Model ◽

Interaction Prediction ◽

Physiologically Based ◽

Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk

Pharmaceutical Research ◽

10.1007/s11095-014-1333-3 ◽

2014 ◽

Vol 31 (9) ◽

pp. 2367-2382 ◽

Cited By ~ 25

Author(s):

Michael Gertz ◽

Nikolaos Tsamandouras ◽

Carolina Säll ◽

J. Brian Houston ◽

Aleksandra Galetin

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Model ◽

Physiologically Based ◽

Drug Drug Interaction ◽

Vitro Data ◽

In Vitro Data

Investigational Small-Molecule Drug Selectively Suppresses Constitutive CYP2B6 Activity at the Gene Transcription Level: Physiologically Based Pharmacokinetic Model Assessment of Clinical Drug Interaction Risk

Drug Metabolism and Disposition ◽

10.1124/dmd.114.057018 ◽

2014 ◽

Vol 42 (6) ◽

pp. 1008-1015 ◽

Cited By ~ 10

Author(s):

Maciej J. Zamek-Gliszczynski ◽

Michael A. Mohutsky ◽

Jessica L. F. Rehmel ◽

Alice B. Ke

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Model ◽

Model Assessment ◽

Transcription Level ◽

Small Molecule Drug ◽

Physiologically Based ◽

Gene Transcription Level ◽

Clinical Drug

Evaluation of drug‐drug interaction potential between omecamtiv mecarbil and rosuvastatin, a BCRP substrate, with a clinical study in healthy subjects and using a physiologically‐based pharmacokinetic model

Clinical and Translational Science ◽

10.1111/cts.13118 ◽

2021 ◽

Author(s):

Ashit Trivedi ◽

Winnie Sohn ◽

Priyanka Kulkarni ◽

Pegah Jafarinasabian ◽

Hanze Zhang ◽

...

Keyword(s):

Drug Interaction ◽

Clinical Study ◽

Interaction Potential ◽

Healthy Subjects ◽

Pharmacokinetic Model ◽

Physiologically Based ◽

Omecamtiv Mecarbil ◽