Randomised Response-Adaptive Designs in Clinical Trials, First Edition Anthony C. Atkinson, Atanu Biswas (2014) Chapman & Hall/CRC Monographs on Statistics & Applied Probability ISBN: 9781584886938 No. of pages: 339 Price: $99.95 (USD)/£71.99 (GBP)

2018 ◽  
Author(s):  
Lauren Bell
Keyword(s):  
Clinical Trials ◽  
Adaptive Designs ◽  
Applied Probability ◽  
Response Adaptive Designs

The use of response-adaptive designs in clinical trials

1993 ◽  
Vol 14 (6) ◽  
pp. 471-484 ◽  
Author(s):  
William F. Rosenberger ◽  
John M. Lachin
Keyword(s):  
Clinical Trials ◽  
Adaptive Designs ◽  
Response Adaptive Designs

scholarly journals A new inferential approach for response-adaptive clinical trials: the variance-stabilized bootstrap

Test ◽  
2021 ◽  
Author(s):  
Alessandro Baldi Antognini ◽  
Marco Novelli ◽  
Maroussa Zagoraiou
Keyword(s):  
Clinical Trials ◽  
Adaptive Designs ◽  
Simulation Studies ◽  
Adaptive Randomization ◽  
Allocation Procedure ◽  
Adaptive Clinical Trials ◽  
Response Adaptive Designs ◽  
Treatment Comparisons

AbstractThis paper discusses disadvantages and limitations of the available inferential approaches in sequential clinical trials for treatment comparisons managed via response-adaptive randomization. Then, we propose an inferential methodology for response-adaptive designs which, by exploiting a variance stabilizing transformation into a bootstrap framework, is able to overcome the above-mentioned drawbacks, regardless of the chosen allocation procedure as well as the desired target. We derive the theoretical properties of the suggested proposal, showing its superiority with respect to likelihood, randomization and design-based inferential approaches. Several illustrative examples and simulation studies are provided in order to confirm the relevance of our results.

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