Nonlinear mixed‐effects modeling of longitudinal count data: Bayesian inference about median counts based on the marginal zero‐inflated discrete Weibull distribution

2021 ◽  
Author(s):  
Divan A. Burger ◽  
Emmanuel Lesaffre
Keyword(s):  
Bayesian Inference ◽  
Weibull Distribution ◽  
Count Data ◽  
Mixed Effects ◽  
Nonlinear Mixed Effects ◽  
Nonlinear Mixed Effects Modeling ◽  
Mixed Effects Modeling ◽  
Longitudinal Count Data

scholarly journals Effect ofSLCO1B1Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis

2015 ◽  
Vol 60 (1) ◽  
pp. 617-620 ◽  
Author(s):  
Stefanie Hennig ◽  
Suhashni Naiker ◽  
Tarylee Reddy ◽  
Deirdre Egan ◽  
Tracy Kellerman ◽  
...  
Keyword(s):  
Drug Exposure ◽  
Mixed Effects ◽  
Nonlinear Mixed Effects ◽  
Nonlinear Mixed Effects Modeling ◽  
Tuberculosis Patients ◽  
Host Genetics ◽  
Mixed Effects Modeling ◽  
Complex Interactions ◽  
Multiple Doses ◽  
Heterozygous Carriers

ABSTRACTRifabutin, used to treat HIV-infected tuberculosis, shows highly variable drug exposure, complicating dosing. Effects ofSLCO1B1polymorphisms on rifabutin pharmacokinetics were investigated in 35 African HIV-infected tuberculosis patients after multiple doses. Nonlinear mixed-effects modeling found that influential covariates for the pharmacokinetics were weight, sex, and a 30% increased bioavailability among heterozygous carriers ofSLCO1B1rs1104581 (previously associated with low rifampin concentrations). Larger studies are needed to understand the complex interactions of host genetics in HIV-infected tuberculosis patients. (This study has been registered at ClinicalTrials.gov under registration no. NCT00640887.)

scholarly journals Nonlinear mixed effects modeling of growth in Japanese quail

2013 ◽  
Vol 92 (7) ◽  
pp. 1942-1948 ◽  
Author(s):  
Emre Karaman ◽  
Dogan Narinc ◽  
Mehmet Ziya Firat ◽  
Tulin Aksoy
Keyword(s):  
Japanese Quail ◽  
Mixed Effects ◽  
Nonlinear Mixed Effects ◽  
Nonlinear Mixed Effects Modeling ◽  
Mixed Effects Modeling

scholarly journals Pharmacokinetic Similarity of Biologics: Analysis Using Nonlinear Mixed-Effects Modeling

2011 ◽  
Vol 91 (2) ◽  
pp. 234-242 ◽  
Author(s):  
A Dubois ◽  
S Gsteiger ◽  
S Balser ◽  
E Pigeolet ◽  
J L Steimer ◽  
...  
Keyword(s):  
Mixed Effects ◽  
Nonlinear Mixed Effects ◽  
Nonlinear Mixed Effects Modeling ◽  
Mixed Effects Modeling

scholarly journals Characterization of intestinal absorption of C -glycoside flavonoid vicenin-2 from Lychnophora ericoides leafs in rats by nonlinear mixed effects modeling

2015 ◽  
Vol 25 (3) ◽  
pp. 212-218 ◽  
Author(s):  
Gabriela A. Buqui ◽  
Sherwin K.B. Sy ◽  
Matilde Merino-Sanjuán ◽  
Dayana R. Gouvea ◽  
Suzana L. Nixdorf ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Mixed Effects ◽  
Nonlinear Mixed Effects ◽  
Nonlinear Mixed Effects Modeling ◽  
Mixed Effects Modeling
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