No Effect of Genetic Polymorphisms on Cyclosporine Pharmacokinetics in Renal Transplant Recipients Based on Nonlinear Mixed Effects Modeling

2016 ◽  
Vol 16 (12) ◽  
pp. 12362-12368 ◽  
Author(s):  
Danying Li ◽  
Jianzhong Rui ◽  
Huaijun Zhu ◽  
Guohua Zhou ◽  
Weihong Ge ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Genetic Polymorphisms ◽  
Mixed Effects ◽  
Renal Transplant Recipients ◽  
Nonlinear Mixed Effects ◽  
Transplant Recipients ◽  
Nonlinear Mixed Effects Modeling ◽  
Mixed Effects Modeling ◽  
Cyclosporine Pharmacokinetics

scholarly journals Effect ofSLCO1B1Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis

2015 ◽  
Vol 60 (1) ◽  
pp. 617-620 ◽  
Author(s):  
Stefanie Hennig ◽  
Suhashni Naiker ◽  
Tarylee Reddy ◽  
Deirdre Egan ◽  
Tracy Kellerman ◽  
...  
Keyword(s):  
Drug Exposure ◽  
Mixed Effects ◽  
Nonlinear Mixed Effects ◽  
Nonlinear Mixed Effects Modeling ◽  
Tuberculosis Patients ◽  
Host Genetics ◽  
Mixed Effects Modeling ◽  
Complex Interactions ◽  
Multiple Doses ◽  
Heterozygous Carriers

ABSTRACTRifabutin, used to treat HIV-infected tuberculosis, shows highly variable drug exposure, complicating dosing. Effects ofSLCO1B1polymorphisms on rifabutin pharmacokinetics were investigated in 35 African HIV-infected tuberculosis patients after multiple doses. Nonlinear mixed-effects modeling found that influential covariates for the pharmacokinetics were weight, sex, and a 30% increased bioavailability among heterozygous carriers ofSLCO1B1rs1104581 (previously associated with low rifampin concentrations). Larger studies are needed to understand the complex interactions of host genetics in HIV-infected tuberculosis patients. (This study has been registered at ClinicalTrials.gov under registration no. NCT00640887.)

Influence of genetic polymorphisms inGSTM1,GSTM3,GSTT1andGSTP1on allograft outcome in renal transplant recipients

2009 ◽  
Vol 23 (4) ◽  
pp. 490-498 ◽  
Author(s):  
Ranjana Singh ◽  
Parmeet K. Manchanda ◽  
Pravin Kesarwani ◽  
Aneesh Srivastava ◽  
Rama D. Mittal
Keyword(s):  
Renal Transplant ◽  
Genetic Polymorphisms ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Allograft Outcome

scholarly journals Nonlinear mixed effects modeling of growth in Japanese quail

2013 ◽  
Vol 92 (7) ◽  
pp. 1942-1948 ◽  
Author(s):  
Emre Karaman ◽  
Dogan Narinc ◽  
Mehmet Ziya Firat ◽  
Tulin Aksoy
Keyword(s):  
Japanese Quail ◽  
Mixed Effects ◽  
Nonlinear Mixed Effects ◽  
Nonlinear Mixed Effects Modeling ◽  
Mixed Effects Modeling
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