Large‐scale chiral supercritical fluid chromatography of a key intermediate in the synthesis of two S1P 1 final active pharmaceutical ingredients

2019 ◽  
Vol 2 (9) ◽  
pp. 343-352 ◽  
Author(s):  
Shiuhang Henry Yip ◽  
Dauh‐Rurng Wu ◽  
James Kempson ◽  
Andres Hernandez ◽  
Huiping Zhang ◽  
...  
Keyword(s):  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Large Scale ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

Improving sensitivity in chiral supercritical fluid chromatography for analysis of active pharmaceutical ingredients

Chirality ◽  
2007 ◽  
Vol 19 (10) ◽  
pp. 787-792 ◽  
Author(s):  
Roy Helmy ◽  
Mirlinda Biba ◽  
Jia Zang ◽  
Bing Mao ◽  
Kimber Fogelman ◽  
...  
Keyword(s):  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

15.1 Flow Chemistry in the Pharmaceutical Industry: Part 1

2018 ◽  
Author(s):  
A. G. O’Brien
Keyword(s):  
Pharmaceutical Industry ◽  
Large Scale ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
Flow Process ◽  
Pharmaceutical Ingredients ◽  
Multistep Synthesis

Abstract The use of flow chemistry in the single- and multistep synthesis of active pharmaceutical ingredients has been well demonstrated. The pharmaceutical industry is now taking the next steps towards integration of flow chemistry into large-scale commercialized processes, which can effectively supply patient populations. This chapter details advances in this area, and outlines the data and knowledge required to select, develop, scale, and commercialize an efficient flow process.

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