This review discusses the diverse enzymatic pathways in the biosynthesis of cyclopropane, a unique structural motif with important biochemical properties.
Investigations into fungal polyketide biosynthesis have revealed many examples of megasynthases and trans-acting accessory enzymes. This review collates the different classes of collaborating enzymes, demonstrating common themes and rarer examples.
Bacterial pathogens can be highly social, communicating and cooperating within multi-cellular groups to make us sick. Manipulating these behaviors might have therapeutic benefits.
This review summarizes the research progress on the structural classification, biological activities and mechanisms, metabolism and pharmacokinetic investigations, biosynthesis, and synthesis and structural modifications of the withanolides.
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as asporychalasin from Aspergillus oryzae.
Anthracyclines are important anticancer drugs. We discuss recent insights into the biosynthetic pathways and bioactivities of anthracyclines, and evaluate the discovery and engineering of effective derivatives with less severe side effects.
Paxilline indole diterpenes have fascinated chemists for the past several decades. This review highlights the diversity of strategies and tactics that have been employed in the corresponding area of organic synthesis, from inception to the present.
It has become a ‘received wisdom’ that there are universal links between natural product (NP) self-resistance and biosynthesis, which needs interpretation. This review highlights evidence of intersection between NP self-resistance and biosynthesis.
This review covers intercellular signalling in the soil microbiome and its importance in regulating key beneficial functions. We consider the possibilities for how we can engineer soil microbiome signalling to unlock tangible benefits to crops.
Cheminformatics analysis shows that most marine microbial natural products are like terrestrial microbial natural products. New methods to access novel marine microbial chemistry are needed.
