Conditioned Taste Aversion and Ca/Calmodulin-Dependent Kinase II in the Parabrachial Nucleus of Rats

2001 ◽  
Vol 76 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Jiri Krivanek
Keyword(s):  
Taste Aversion ◽  
Conditioned Taste Aversion ◽  
Parabrachial Nucleus

scholarly journals Gfral-expressing Neurons Suppress Food Intake via Aversive Pathways

2020 ◽  
Author(s):  
Paul V. Sabatini ◽  
Henriette Frikke-Schmidt ◽  
Joe Arthurs ◽  
Desiree Gordian ◽  
Anita Patel ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Taste Aversion ◽  
Conditioned Taste Aversion ◽  
Mechanisms Of Action ◽  
Parabrachial Nucleus ◽  
Gastric Physiology ◽  
Anorexigenic Peptide ◽  
Artificial Activation ◽  
Meal Ingestion

AbstractTo determine the function and mechanisms of action for hindbrain neurons that express GFRAL, the receptor for the anorexigenic peptide, GDF-15, we generated Gfralcre and conditional GfralCreERT mice. While signals of infection or pathophysiologic states (rather than meal ingestion) stimulate GFRAL neurons, the artificial activation of GfralCre- expressing neurons inhibited feeding, decreased gastric emptying, and promoted a conditioned taste aversion (CTA). Additionally, activation of the smaller population of GFRAL neurons captured by the GfralCreERT allele decreased gastric emptying and produced a CTA without suppressing food intake, suggesting that GFRAL neurons primarily modulate gastric physiology and stimulate aversive responses. GFRAL neurons most strongly innervated the parabrachial nucleus (PBN), where they targeted CGRP-expressing (CGRPPBN) neurons. Silencing CGRPPBN neurons abrogated the aversive and anorexic effects of GDF-15. These findings suggest that GFRAL neurons link non-meal-associated, pathophysiologic signals to the aversive suppression of nutrient uptake and absorption.

2116 C-fos expression in the parabrachial nucleus after acquisition of conditioned taste aversion in the rat

1993 ◽  
Vol 18 ◽  
pp. S230
Author(s):  
Takashi Yamamoto ◽  
Tsuyoshi Shimura ◽  
Noritaka Sako ◽  
Norimi Ozaki ◽  
Nobuyuki Sakai ◽  
...  
Keyword(s):  
Taste Aversion ◽  
Conditioned Taste Aversion ◽  
Parabrachial Nucleus ◽  
Fos Expression

Glutamate in the parabrachial nucleus of rats during conditioned taste aversion

2000 ◽  
Vol 887 (2) ◽  
pp. 413-417 ◽  
Author(s):  
Edita Bielavska ◽  
Ivan Miksik ◽  
Jiri Krivanek
Keyword(s):  
Taste Aversion ◽  
Conditioned Taste Aversion ◽  
Parabrachial Nucleus

Induction of a brainstem correlate of conditioned taste aversion expression: role of the pontine parabrachial nucleus

2002 ◽  
Vol 131 (1-2) ◽  
pp. 205-209 ◽  
Author(s):  
Matilde Lopez Grancha ◽  
Montserrat Navarro ◽  
Imaculada Cubero ◽  
Todd E Thiele ◽  
Ilene L Bernstein
Keyword(s):  
Taste Aversion ◽  
Conditioned Taste Aversion ◽  
Parabrachial Nucleus
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