Since the usable range of the frequency spectrum is limited, the frequency assignment problem (FAP) is important in mobile telephone communication. In this paper, according to the characteristics of engineering- oriented FAP, an engineering-oriented hybrid genetic algorithm (EHGA) based on traditional genetic algorithm (TGA) is proposed, combined with particle swarm optimization (PSO) and simulated annealing (SA). The results obtained by the simulation to a real-word FAP case in GSM show that the algorithm we proposed is a better approach to solve the engineering-oriented FAP.