Substance P and Hypoxic Excitation of the Carotid Body

1987 ◽  
pp. 263-265
Author(s):  
N. R. Prabhakar ◽  
J. Mitra ◽  
H. Lagercrantz ◽  
C. von Euler ◽  
N. S. Cherniack
Keyword(s):  
Substance P ◽  
Carotid Body

Role of Substance P in Neutral Endopeptidase Modulation of Hypoxic Response of the Carotid Body

2002 ◽  
pp. 705-713 ◽  
Author(s):  
Ganesh K. Kumara ◽  
Yu Ru-Koub ◽  
Jeffrey L. Overholtb ◽  
Nanduri R. Prabhakarb
Keyword(s):  
Substance P ◽  
Carotid Body ◽  
Neutral Endopeptidase ◽  
Hypoxic Response

The Use of NK-1 Receptor Null Mice to Assess the Significance of Substance P in the Carotid Body Function.

2003 ◽  
pp. 327-336 ◽  
Author(s):  
A. J. Rico ◽  
J. Prieto-Lloret ◽  
D. F. Donnelly ◽  
C. de Felipe ◽  
Constancio Gonzalez ◽  
...  
Keyword(s):  
Substance P ◽  
Carotid Body ◽  
Body Function

Substance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial pO2

1989 ◽  
Vol 481 (2) ◽  
pp. 205-214 ◽  
Author(s):  
Nanduri R. Prabhakar ◽  
Story C. Landis ◽  
Ganesh K. Kumar ◽  
Debra Mullikin-Kilpatrick ◽  
Neil S. Cherniack ◽  
...  
Keyword(s):  
Substance P ◽  
Carotid Body ◽  
Neurokinin A ◽  
Arterial Po2

Ventilatory effects of substance P, vasoactive intestinal peptide, and nitroprusside in humans

1990 ◽  
Vol 68 (1) ◽  
pp. 295-301 ◽  
Author(s):  
D. L. Maxwell ◽  
R. W. Fuller ◽  
C. M. Dixon ◽  
F. M. Cuss ◽  
P. J. Barnes
Keyword(s):  
Substance P ◽  
Vasoactive Intestinal Peptide ◽  
Carotid Body ◽  
Animal Studies ◽  
Ventilatory Response ◽  
Hypoxic Ventilatory Response ◽  
Peripheral Chemoreceptor ◽  
Hypotensive Action ◽  
Ventilatory Effects ◽  
Stimulation Of

Animal studies suggest that the neuropeptides, substance P and vasoactive intestinal peptide (VIP), may influence carotid body chemoreceptor activity and that substance P may take part in the carotid body response to hypoxia. The effects of these peptides on resting ventilation and on ventilatory responses to hypoxia and to hypercapnia have been investigated in six normal humans. Infusions of substance P (1 pmol.kg-1.min-1) and of VIP (6 pmol.kg-1.min-1) were compared with placebo and with nitroprusside (5 micrograms.kg-1.min-1) as a control for the hypotensive action of the peptides. Both peptides caused significantly less hypotension than nitroprusside. Substance P and nitroprusside caused significantly greater increases in ventilation and in the hypoxic ventilatory response than VIP. No changes were seen in hypercapnic sensitivity. The stimulation of ventilation and the differential effects on ventilatory chemosensitivity that accompanied hypotension are consistent either with stimulation of carotid body chemoreceptor activity or with an interaction with peripheral chemoreceptor input to the respiratory center, as is seen in animals. The similar cardiovascular but different ventilatory effects of the peptides suggest that substance P may also stimulate the carotid body in a manner independent of the effect of hypotension. This is consistent with a role of substance P in the hypoxic ventilatory response in humans.

Peptides in the cat carotid body (glomus caroticum): VIP-, enkephalin-, and substance P-like immunoreactivity

1979 ◽  
Vol 107 (3) ◽  
pp. 279-281 ◽  
Author(s):  
JAN M. LUNDBERG ◽  
TOMAS HÖKFELT ◽  
JAN FAHRENKRUG ◽  
GÖRAN NILSSON ◽  
LARS TERENIUS
Keyword(s):  
Substance P ◽  
Carotid Body ◽  
Glomus Caroticum

Physiological chemoreceptor stimulation decreases enkephalin and substance P in the carotid body

Peptides ◽  
1986 ◽  
Vol 7 (5) ◽  
pp. 767-769 ◽  
Author(s):  
G. Hanson ◽  
L. Jones ◽  
S. Fidone
Keyword(s):  
Substance P ◽  
Carotid Body

Substance P: A carotid body peptide

1980 ◽  
Vol 17 (1-2) ◽  
pp. 215-219 ◽  
Author(s):  
A.C. Cuello ◽  
D.S. McQueen
Keyword(s):  
Substance P ◽  
Carotid Body

studies on the hydrolysis of substance P by proteases of carotid body

1988 ◽  
Vol 22 (1-2) ◽  
pp. 107 ◽  
Author(s):  
G.K. Kumar ◽  
N.R. Prabhakar ◽  
N.S. Cherniack
Keyword(s):  
Substance P ◽  
Carotid Body ◽  
Hydrolysis Of
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