Renal Hypertension | ScienceGate

ROLE OF THE THYROID GLAND IN DEVELOPMENT AND MAINTENANCE OF RENAL HYPERTENSION IN RATS

Acta Endocrinologica ◽

10.1530/acta.0.xxxiv0411 ◽

1960 ◽

Vol XXXIV (III) ◽

pp. 411-429 ◽

Cited By ~ 3

Author(s):

Melvin J. Fregly ◽

Kenneth M. Cook

Keyword(s):

Blood Pressure ◽

Rate Increase ◽

Renal Hypertension ◽

The Other ◽

Elevated Blood Pressure ◽

Unit Weight ◽

Elevated Blood ◽

Inhibition Of Growth ◽

Testicular Size

ABSTRACT The anti-thyroid drugs, thiouracil, propylthiouracil, and methimazole, prevented both development of elevated blood pressure and cardiac hypertrophy usually accompanying kidney encapsulation with latex envelopes. These drugs also reduced elevated blood pressure of rats with hypertension of 13 to 40 weeks' duration prior to drug administration. Addition of desiccated thyroid powder to diet containing an anti-thyroid drug overcame the anti-hypertensive effect of the latter. Withdrawal of thyroid powder only was followed by return of blood pressure to previous low level within 3 weeks. The results suggest that the anti-hypertensive effect of these drugs is related directly to the hypothyroidism produced rather than to extrathyroidal effects of the drugs. Comparison of potencies of the 3 drugs in terms of anti-hypertensive effect, inhibition of growth rate, increase in testicular size, and increase in thyroid size suggests that propylthiouracil and methimazole are equally potent per unit weight of drug. Thiouracil has approximately half the potency of the other two.

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Role of renin in the pathogenesis of renal hypertension.

Circulation Research ◽

10.1161/01.res.36.6.187 ◽

1975 ◽

Vol 36 (6) ◽

pp. 187-193 ◽

Cited By ~ 13

Author(s):

O P Gulati ◽

O A Carretero ◽

N B Oza ◽

L A Fernandez ◽

A Schork

Keyword(s):

Renal Hypertension

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Role of Autonomic Nervous System in Maintenance of Cerebral and Renal Hypertension

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1957.188.2.371 ◽

1957 ◽

Vol 188 (2) ◽

pp. 371-374 ◽

Cited By ~ 2

Author(s):

Sol Rothman ◽

Douglas R. Drury

Keyword(s):

Blood Pressure ◽

Nervous System ◽

Autonomic Nervous System ◽

Renal Hypertension ◽

The Other ◽

Peripheral Vasculature ◽

Blood Pressures ◽

Sympathetic Nervous ◽

Blood Pressure Responses

The blood pressure responses to various drugs were investigated in renal hypertensive, cerebral hypertensive and normotensive rabbits. Hexamethonium bromide and Dibenamine reduced the blood pressures of renal and cerebral hypertensives. Effects in the normal were insignificant. The cerebral hypertensive's blood pressure was slightly affected by benzodioxane. Blood pressure was not reduced at all in the other groups. Blood pressure of the renal hypertensive rabbit was greatly reduced by Veriloid and dihydroergocornine. Blood pressures of cerebral and normal animals were affected to a lesser degree. The results suggest that maintenance of hypertension in the cerebral hypertensive rabbit depends on an overactive sympathetic nervous system, possibly due to the release of medullary pressor centers from inhibitory impulses originating in higher centers; whereas, the maintenance of hypertension in the renal hypertensive rabbit may be attributed to an increased reactivity of the peripheral vasculature to a normal sympathetic tone.

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