nervous system
Recently Published Documents


TOTAL DOCUMENTS

78163
(FIVE YEARS 17438)

H-INDEX

377
(FIVE YEARS 65)

Author(s):  
Andreia Fuentes Santos ◽  
◽  
Marilia Moraes Queiroz Souza ◽  
Karoline Bach Pauli ◽  
Gustavo Ratti da Silva ◽  
...  

Bacopa monnieri(L.) Wettst. (Plantaginaceae), also known as Brahmi, has been used to improve cognitive processes and intellectual functions that are related to the preservation of memory. The objective of this research is to review the ethnobotanical applications, phytochemical composition, toxicity and activity of B. monnieriin the central nervous system. It reviewed articles on B. monnieriusing Google Scholar, SciELO, Science Direct, Lilacs, Medline, and PubMed. Saponins are the main compounds in extracts of B. monnieri. Pharmacological studies showed that B. monnieriimproves learning and memory and presents biological effects against Alzheimer’s disease, Parkinson’s disease, epilepsy, and schizophrenia. No preclinical acute toxicity was reported. However, gastrointestinal side effects were reported in some healthy elderly individuals. Most studies with B. monnierihave been preclinical evaluations of cellular mechanisms in the central nervous system and further translational clinical research needs to be performed to evaluate the safety and efficacy of the plant.


2022 ◽  
Vol 15 ◽  
Author(s):  
Krissy A. Lyon ◽  
Nicola J. Allen

Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior. Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes influence synapse formation, function, and plasticity. Beyond the synapse, recent research has revealed that astrocyte influences on the nervous system extend to the modulation of neuronal circuitry and behavior. Here we review recent findings on the active role of astrocytes in behavioral modulation with a focus on in vivo studies, primarily in mice. Using tools to acutely manipulate astrocytes, such as optogenetics or chemogenetics, studies reviewed here have demonstrated a causal role for astrocytes in sleep, memory, sensorimotor behaviors, feeding, fear, anxiety, and cognitive processes like attention and behavioral flexibility. Current tools and future directions for astrocyte-specific manipulation, including methods for probing astrocyte heterogeneity, are discussed. Understanding the contribution of astrocytes to neuronal circuit activity and organismal behavior will be critical toward understanding how nervous system function gives rise to behavior.


2022 ◽  
Vol 62 ◽  
pp. 130-136
Author(s):  
Steve S. Saitoh ◽  
Shogo Tanabe ◽  
Rieko Muramatsu

2022 ◽  
Vol 36 (1) ◽  
pp. 147-159
Author(s):  
Ugonma Chukwueke ◽  
Christian Grommes ◽  
Lakshmi Nayak

2022 ◽  
Vol 36 (1) ◽  
pp. 23-42
Author(s):  
Stephen S. Francis ◽  
Quinn T. Ostrom ◽  
David J. Cote ◽  
Timothy R. Smith ◽  
Elizabeth Claus ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document