Voltage Clamp Studies Of Calcium Channel Blockage in the Heart

1984 ◽  
pp. 47-62
Author(s):  
R. S. Kass ◽  
M. C. Sanguinetti
Keyword(s):  
Calcium Channel ◽  
Voltage Clamp ◽  
Channel Blockage

scholarly journals Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

2018 ◽  
Vol 12 (1) ◽  
pp. 11-18 ◽  
Author(s):  
de Souza Monteiro Fabio ◽  
Felipe Silva Carvalho Antonio ◽  
de Castro Marques Elismar ◽  
Melo Ribeiro Rachel ◽  
Carlos Romao Borges Antonio ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Syzygium Cumini ◽  
Antispasmodic Activity ◽  
Channel Blockage

IATROGENIC HYPERCALCEMIA INDUCED PANCREATITIS FOLLOWING TREATMENT OF OCCULT CALCIUM CHANNEL BLOCKAGE

CHEST Journal ◽  
2019 ◽  
Vol 156 (4) ◽  
pp. A2255 ◽  
Author(s):  
Salman Khan ◽  
Faraz Siddiqui ◽  
Kim Norville ◽  
Imran Khan ◽  
Apurwa Karki
Keyword(s):  
Calcium Channel ◽  
Channel Blockage

Vasorelaxant effect in rat aortic rings through calcium channel blockage: A preliminary in vitro assessment of a 1,3,4-oxadiazole derivative

2009 ◽  
Vol 181 (3) ◽  
pp. 377-382 ◽  
Author(s):  
Girish R. Bankar ◽  
K. Nandakumar ◽  
Pawan G. Nayak ◽  
Anjali Thakur ◽  
Mallikarjuna Rao Chamallamudi ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Vasorelaxant Effect ◽  
Channel Blockage ◽  
In Vitro Assessment

scholarly journals Discovery of Novel Leishmanicidal Drugs with Potential L-type Calcium Channel Blockage, Designed by Similarity-Based Virtual Screening Approaches

2017 ◽  
pp. 01-06
Author(s):  
Leonardo B. Federico ◽  
Laura M. Alcântara ◽  
Carolina B. Moraes ◽  
Lucio H. Freitas-Junior ◽  
Joaquín M. C. Rosa ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Calcium Channel ◽  
Therapeutic Strategy ◽  
Moderate Activity ◽  
Intracellular Parasites ◽  
Synthetic Accessibility ◽  
Content Analyses ◽  
Channel Blockage ◽  
Control Compound ◽  
Screening Approaches

Calcium channel blockage as a therapeutic strategy for treatment of leishmaniasis has demonstrated a promising pathway of treatment for this pathology. In this work, virtual screening approaches have been performed in several databases of commercially available compounds in order to design novel leishmanicidal compounds with potential L-type calcium channel blockage. Several compounds were tested against Leishmania intracellular parasites, using High-Content Analyses Assays. Results have indicated two compounds with new chemotypes, which were able to kill the parasite, with moderate activity and high efficacy, without toxicity for the host. Compounds here discovered represent a very useful molecular simplification compared to the reference or control compound, amphotericin B, with suitable ADME/Tox properties and synthetic accessibility.

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