The Intracellular Distribution of Adenosine Triphosphate

The intracellular distribution of the hexokinase of the adrenal medulla was studied. Most of the hexokinase was found, in about equal amounts, in the mitochondria and the nonparticulate cytoplasm. The amount of hexokinase associated with the mitochondria was shown to be dependent on the hexokinase concentration in the medium surrounding the mitochondria.The hexokinase of the adrenal medulla was shown to be noncompetitively inhibited by adenosine diphosphate (ADP) with respect to glucose and adenosine triphosphate (ATP). It was competitively inhibited with respect to glucose by mannose, fructose, and galactose. Glucose-6-phosphate (0.09 M) did not inhibit the hexokinase. The data on product inhibition and initial velocity analysis support the concept of an ordered sequential mechanism for adrenal-medulla hexokinase.

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Content and Intracellular Distribution of Adenosine Triphosphate in Cow Adrenal Medulla1

Acta Physiologica Scandinavica ◽

10.1111/j.1748-1716.1956.tb01332.x ◽

1956 ◽

Vol 36 (4) ◽

pp. 360-376 ◽

Cited By ~ 72

Author(s):

BENGT FALCK ◽

NILS-AKE HILLARP ◽

BERTIL HOGBERG

Keyword(s):

Adenosine Triphosphate ◽

Intracellular Distribution

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882 Adenosine triphosphate test: is it dangerous?

EP Europace ◽

10.1016/s1099-5129(05)80633-6 ◽

2005 ◽

Vol 7 ◽

pp. 215-215

Keyword(s):

Adenosine Triphosphate

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QTc Dispersion Correlates With the Imaging Patterns on Adenosine Triphosphate Stress Thallium-201

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)84273-8 ◽

1998 ◽

Vol 31 (2) ◽

pp. 131A

Author(s):

H Teragawa

Keyword(s):

Adenosine Triphosphate ◽

Thallium 201 ◽

Qtc Dispersion

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Heparin from Intestine and Lung Source Administered in Large Dose to Dogs with Acute Myocardial Ischemia

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648674 ◽

1978 ◽

Vol 40 (02) ◽

pp. 407-417

Author(s):

Michael J Saliba ◽

Richard J Pavalec

Keyword(s):

Coronary Artery ◽

Myocardial Ischemia ◽

Adenosine Triphosphate ◽

Intestinal Mucosa ◽

Large Dose ◽

Acute Myocardial Ischemia ◽

Ischemic Myocardium ◽

Atp Levels ◽

Initial Control ◽

The Difference

SummaryIntestinal mucosa heparin (IMH) and beef lung heparin (BLH) were infused into dogs subjected to myocardial ischemia by intermittent coronary artery occlusions. The IMH was from a mixture of beef, sheep, and pig intestinal mucosa. Initial control occlusion and recovery was followed by a second occlusion with 60,000 units of IMH or BLH added. Electrocardiographic S-T segment elevations (ST) were measured acutely. There were no significant differences in ST in non-ischemic myocardium before occlusions or with occlusions. In ischemic myocardium, IMH significantly lowered control ST 84% in amount (t = 6.1 p <0.00005), and 76% in number (t = 11.6 p <0.00001). BLH lowered control ST a significant, lesser, 36% in amount (t = 3.6 p <0.008), and 35% in number (t = 3.2 p <0.01). The difference between IMH and BLH in ischemic myocardium was a significant 48% in amount (t = 4.0 p <0.0007), and 41% in number (t = 2.0 p <0.06). Myocardial adenosine triphosphate (ATP) levels were assayed after 90 min. ATP levels were 31% higher in both ischemic and non-ischemic myocardium in IMH-treated dogs than in BLH- treated. It was concluded that IMH and BLH are functionally different, and IMH was significantly more effective.

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