Principles of Protein X-ray Crystallography

1999 ◽  
Author(s):  
Jan Drenth
Keyword(s):  
X Ray ◽  
X Ray Crystallography ◽  
Protein X

Protein X-ray Crystallography in Drug Discovery

2005 ◽  
pp. 373-455 ◽  
Author(s):  
Peter Nollert ◽  
Michael D. Feese ◽  
Bart L. Staker ◽  
Hidong Kim
Keyword(s):  
Drug Discovery ◽  
X Ray ◽  
X Ray Crystallography ◽  
Protein X

scholarly journals High-Pressure Protein X-Ray Crystallography

2017 ◽  
Vol 27 (1) ◽  
pp. 18-25
Author(s):  
Nobuhisa WATANABE ◽  
Hiroyuki YAMADA ◽  
Takayuki NAGAE
Keyword(s):  
High Pressure ◽  
X Ray ◽  
X Ray Crystallography ◽  
Protein X

Principles of Protein X-Ray Crystallography. Jan Drenth

2000 ◽  
Vol 75 (1) ◽  
pp. 48-48
Author(s):  
Gregory A. Petsko
Keyword(s):  
X Ray ◽  
X Ray Crystallography ◽  
Protein X

Incorporation of β-selenolo[3,2-b]pyrrolyl-alanine into proteins for phase determination in protein X-ray crystallography

2001 ◽  
Vol 309 (4) ◽  
pp. 925-936 ◽  
Author(s):  
Jae Hyun Bae ◽  
Stefan Alefelder ◽  
Jens T Kaiser ◽  
Rainer Friedrich ◽  
Luis Moroder ◽  
...  
Keyword(s):  
Phase Determination ◽  
X Ray ◽  
X Ray Crystallography ◽  
Protein X

scholarly journals Protein X-ray crystallography of the 14-3-3ζ/SOS1 complex

Data in Brief ◽  
2018 ◽  
Vol 19 ◽  
pp. 1683-1687 ◽  
Author(s):  
Alice Ballone ◽  
Federica Centorrino ◽  
Madita Wolter ◽  
Christian Ottmann
Keyword(s):  
X Ray ◽  
X Ray Crystallography ◽  
Protein X

scholarly journals O-Alkylated heavy atom carbohydrate probes for protein X-ray crystallography: Studies towards the synthesis of methyl 2-O-methyl-L-selenofucopyranoside

2016 ◽  
Vol 12 ◽  
pp. 2828-2833 ◽  
Author(s):  
Roman Sommer ◽  
Dirk Hauck ◽  
Annabelle Varrot ◽  
Anne Imberty ◽  
Markus Künzler ◽  
...  
Keyword(s):  
Heavy Atom ◽  
Laccaria Bicolor ◽  
Synthetic Route ◽  
Lectin Receptors ◽  
X Ray ◽  
X Ray Crystallography ◽  
Carbohydrate Epitopes ◽  
Protein X ◽  
Hydroxy Groups

Selenoglycosides are used as reactive glycosyl donors in the syntheses of oligosaccharides. In addition, such heavy atom analogs of natural glycosides are useful tools for structure determination of their lectin receptors using X-ray crystallography. Some lectins, e.g., members of the tectonin family, only bind to carbohydrate epitopes with O-alkylated ring hydroxy groups. In this context, we report the first synthesis of an O-methylated selenoglycoside, specifically methyl 2-O-methyl-L-selenofucopyranoside, a ligand of the lectin tectonin-2 from the mushroom Laccaria bicolor. The synthetic route required a strategic revision and further optimization due to the intrinsic lability of alkyl selenoglycosides, in particular for the labile fucose. Here, we describe a successful synthetic access to methyl 2-O-methyl-L-selenofucopyranoside in 9 linear steps and 26% overall yield starting from allyl L-fucopyranoside.

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