The Role of Adenosine A2a Receptors in Regulating Gabaergic Synaptic Transmission in Striatal Medium Spiny Neurons

1996 ◽  
pp. 119-122 ◽  
Author(s):  
Akihisa Mori ◽  
Tomomi Shindou ◽  
Michio Ichimura ◽  
Hiromi Nonaka ◽  
Hiroshi Kase
Keyword(s):  
Synaptic Transmission ◽  
Medium Spiny Neurons ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Spiny Neurons ◽  
Adenosine A2a ◽  
Gabaergic Synaptic Transmission

scholarly journals Presynaptic adenosine A2A receptors enhance GABAergic synaptic transmission via a cyclic AMP dependent mechanism in the rat globus pallidus

2002 ◽  
Vol 136 (2) ◽  
pp. 296-302 ◽  
Author(s):  
Tomomi Shindou ◽  
Hiromi Nonaka ◽  
Peter J Richardson ◽  
Akihisa Mori ◽  
Hiroshi Kase ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Synaptic Transmission ◽  
Globus Pallidus ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a ◽  
Gabaergic Synaptic Transmission ◽  
Dependent Mechanism

THE ROLE OF ADENOSINE A2A RECEPTORS IN THE NEUROLEPTIC-INDUCED c-Fos EXPRESSION

1998 ◽  
Vol 9 (Supplement) ◽  
pp. S93
Author(s):  
J. Wardasa ◽  
A. Pinna ◽  
A. Cozzolino ◽  
M. Morellib
Keyword(s):  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Fos Expression ◽  
Adenosine A2a

Actions of Adenosine A2A Receptors on Synaptic Connections of Spiny Projection Neurons in the Neostriatal Inhibitory Network

2008 ◽  
Vol 99 (4) ◽  
pp. 1884-1889 ◽  
Author(s):  
Tomomi Shindou ◽  
Gordon W. Arbuthnott ◽  
Jeffery R. Wickens
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Synaptic Transmission ◽  
Projection Neurons ◽  
Synaptic Connections ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Cells Of Origin ◽  
Adenosine A2a ◽  
Whole Cell Recordings

There is growing evidence that adenosine plays a crucial role in basal ganglia function, particularly in the modulation of voluntary movement. An adenosine-based treatment for Parkinson's disease shows promise in recent clinical studies. Adenosine A2A receptors, the receptors involved in this treatment, are highly expressed in the neostriatum. Previous studies have suggested opposing actions of these receptors on synaptic transmission at striatal and pallidal terminals of the same spiny projection neurons, but the cells of origin of the intrastriatal terminals mediating these actions have not been identified. We used dual whole cell recordings to record simultaneously from pairs of striatal cells; this enabled definitive identification of the presynaptic and postsynaptic cells mediating the effects of A2A receptors. We found that A2A receptors facilitate GABAergic synaptic transmission by intrastriatal collaterals of the spiny projection neurons, consistent with their previously reported actions on synaptic transmission at pallidal terminals. This neuromodulatory action on lateral inhibition in the striatum may underlie, in part, the therapeutic efficacy of adenosine-based treatments for Parkinson's disease.

Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex

2018 ◽  
Vol 47 (9) ◽  
pp. 1127-1134 ◽  
Author(s):  
Joana I. Real ◽  
Ana Patrícia Simões ◽  
Rodrigo A. Cunha ◽  
Samira G. Ferreira ◽  
Daniel Rial
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Transmission ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Dopamine D2 ◽  
Adenosine A2a

THE ROLE OF ADENOSINE A2A RECEPTORS IN THE NEUROLEPTIC-INDUCED c-Fos EXPRESSION

1998 ◽  
Vol 9 (1) ◽  
pp. S93
Author(s):  
J. Wardasa ◽  
A. Pinna ◽  
A. Cozzolino ◽  
M. Morellib
Keyword(s):  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Fos Expression ◽  
Adenosine A2a

THE ROLE OF ADENOSINE A2A RECEPTORS IN THE NEUROLEPTIC-INDUCED c-Fos EXPRESSION

1998 ◽  
Vol 9 (1) ◽  
pp. S93
Author(s):  
J. Wardasa ◽  
A. Pinna ◽  
A. Cozzolino ◽  
M. Morellib
Keyword(s):  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Fos Expression ◽  
Adenosine A2a
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