Connecting the Inner Ear to the Central Auditory System: Molecular Development and Characteristics of the Primary Auditory Neurons and Their Network

2015 ◽  
pp. 1-10 ◽  
Author(s):  
Alain Dabdoub ◽  
Bernd Fritzsch
Keyword(s):  
Inner Ear ◽  
Auditory System ◽  
Central Auditory System ◽  
Auditory Neurons

Central Auditory System Responses from Children While Listening to Speech in Noise

2021 ◽  
pp. 108165
Author(s):  
Carlos R. Benítez-Barrera ◽  
Alexandra P. Key ◽  
Todd Andrew Ricketts ◽  
Anne Marie Tharpe
Keyword(s):  
Auditory System ◽  
Central Auditory System ◽  
Speech In Noise

scholarly journals Expression patterns of estrogen receptors in the central auditory system change in prepubertal and aged mice

Neuroscience ◽  
2010 ◽  
Vol 170 (4) ◽  
pp. 1270-1281 ◽  
Author(s):  
K. Charitidi ◽  
R.D. Frisina ◽  
O.N. Vasilyeva ◽  
X. Zhu ◽  
B. Canlon
Keyword(s):  
Estrogen Receptors ◽  
Auditory System ◽  
Expression Patterns ◽  
System Change ◽  
Central Auditory System ◽  
Aged Mice

scholarly journals Deafness-in-a-dish: modeling hereditary deafness with inner ear organoids

2021 ◽  
Author(s):  
Daniel R. Romano ◽  
Eri Hashino ◽  
Rick F. Nelson
Keyword(s):  
Animal Models ◽  
Inner Ear ◽  
Auditory System ◽  
Hearing Aids ◽  
Molecular Mechanisms ◽  
Functional Disability ◽  
Experimental Studies ◽  
Hereditary Deafness ◽  
Human Auditory System ◽  
Human Inner Ear

AbstractSensorineural hearing loss (SNHL) is a major cause of functional disability in both the developed and developing world. While hearing aids and cochlear implants provide significant benefit to many with SNHL, neither targets the cellular and molecular dysfunction that ultimately underlies SNHL. The successful development of more targeted approaches, such as growth factor, stem cell, and gene therapies, will require a yet deeper understanding of the underlying molecular mechanisms of human hearing and deafness. Unfortunately, the human inner ear cannot be biopsied without causing significant, irreversible damage to the hearing or balance organ. Thus, much of our current understanding of the cellular and molecular biology of human deafness, and of the human auditory system more broadly, has been inferred from observational and experimental studies in animal models, each of which has its own advantages and limitations. In 2013, researchers described a protocol for the generation of inner ear organoids from pluripotent stem cells (PSCs), which could serve as scalable, high-fidelity alternatives to animal models. Here, we discuss the advantages and limitations of conventional models of the human auditory system, describe the generation and characteristics of PSC-derived inner ear organoids, and discuss several strategies and recent attempts to model hereditary deafness in vitro. Finally, we suggest and discuss several focus areas for the further, intensive characterization of inner ear organoids and discuss the translational applications of these novel models of the human inner ear.

scholarly journals Loss of the Cochlear Amplifier Prestin Reduces Temporal Processing Efficacy in the Central Auditory System

2018 ◽  
Vol 12 ◽  
Author(s):  
Joseph P. Walton ◽  
Adam C. Dziorny ◽  
Olga N. Vasilyeva ◽  
Anne E. Luebke
Keyword(s):  
Auditory System ◽  
Temporal Processing ◽  
Cochlear Amplifier ◽  
Central Auditory System

Temporal selectivity in the central auditory system of the leopard frog

Science ◽  
1983 ◽  
Vol 219 (4588) ◽  
pp. 1087-1089 ◽  
Author(s):  
G Rose ◽  
R. Capranica
Keyword(s):  
Auditory System ◽  
Leopard Frog ◽  
Central Auditory System
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