Development, Aging, and Plasticity of Perivascular Autonomic Nerves

Author(s):  
Tim Cowen ◽  
Geoffrey Burnstock
Keyword(s):  
2004 ◽  
Vol 35 (03) ◽  
Author(s):  
A Ebersberger ◽  
H Takac ◽  
HG Schaible ◽  
F Richter

2015 ◽  
Vol 18 ◽  
pp. 279-326
Author(s):  
Jong-Sang Kim ◽  
Jun-Youn Shim
Keyword(s):  

1955 ◽  
Vol 129 (2) ◽  
pp. 375-413 ◽  
Author(s):  
Chester L. Yntema ◽  
Warner S. Hammond

2010 ◽  
Vol 13 (4) ◽  
pp. 183-188 ◽  
Author(s):  
Daiki Kubomura ◽  
Yoshiharu Matahira ◽  
Katsuya Nagai ◽  
Akira Niijima
Keyword(s):  

2010 ◽  
Vol 10 (4) ◽  
pp. 498-501 ◽  
Author(s):  
Isao Matsumoto ◽  
Mami Kaneko ◽  
Makoto Oda ◽  
Go Watanabe
Keyword(s):  

1985 ◽  
Vol 133 (2) ◽  
pp. 207-212 ◽  
Author(s):  
Herbert Lepor ◽  
Marjorie Gregerman ◽  
Ranice Crosby ◽  
Fathollah K. Mostofi ◽  
Patrick C. Walsh

2003 ◽  
Vol 121 (5) ◽  
pp. 299-306
Author(s):  
Yojiro UKAI ◽  
Kumiko NODA ◽  
Noboru TODA

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Ian A White ◽  
Julie Gordon ◽  
Wayne Balkan ◽  
Joshua M Hare

Rationale: Established animal models of tissue and limb regeneration demonstrate a critical dependence on concurrent reinnervation by the peripheral nervous system. The abundance of autonomic nerves in the mammalian heart suggests they play a similar role in the response to cardiac injury. Objective: To test the hypothesis that reinnervation is required for innate neonatal cardiac regeneration. Methods and Results: Crossing Wnt1:cre transgenic mice with a double-tandem (td) tomato reporter strain identified all neural crest-derived cell lineages including the peripheral autonomic nerves in the heart. Whole mount epi-fluorescence microscopy facilitated the clear resolution of subepicardial autonomic nerves in the mouse ventricles providing unprecedented detail of the subepicardial neuroanatomy of the mouse heart. We confirmed that sympathetic nerve structures envelop the entire heart, and importantly, exhibit robust re-growth into the regenerating myocardium following resection of the left ventricular apex in neonatal mice. While innervated hearts regenerate with minimal scarring to the left ventricular myocardium, we report that innate cardiac regeneration was inhibited following sympathectomy, as determined by cross-sectional percentage of viable LV myocardium (n=9, 0.87±1.4% vs. n=6, 14.05±4.4% ; p<0.01). Conclusions: Ablation of post-ganglionic sympathetic nerves blocks the innate regenerative capacity of neonatal mouse hearts. Therefore, the innate ability of the neonatal mouse heart to undergo regeneration in response to injury is dependent on sympathetic innervation of the ventricular myocardium. This finding has significant implications for adult regeneration following myocardial infarction where nerve growth is hindered by age related influences and scar tissue.


2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Taku Kitano ◽  
Daiki Yasukawa ◽  
Yuki Aisu ◽  
Tomohide Hori

Laparoscopic gastrectomy is a treatment for gastric cancer, and isoperistaltic side-to-side reconstruction is called “overlap anastomosis.” The physiological advantages of preserving the autonomic nerves in the jejunal limb for digestive reconstruction are well known. Here, we focused on overlap anastomosis with autonomic nerve-preserved mesojejunum of the lifted jejunal limb for laparoscopic distal gastrectomy with intentional lymph node dissection. Our surgical techniques and technical pitfalls were described in detail. The jejunum was partially sacrificed to preserve the autonomic nerves in the lifted jejunal limb. The length of the staple line was 35 – 40 mm. The endostapler entry was carefully closed to avoid even subtle stenosis. Twelve patients were retrospectively evaluated with a follow-up of 5.0 ± 0.6 years. Histological findings according to the Japanese classification were stage IA or IB. Dietary intake and postoperative ambulation occurred at 3.3 ± 1.0 and 1.3 ± 0.5 days after surgery, respectively. Postoperative complications according to Clavien–Dindo classification were one each of grade I and grade II. Postoperative hospital stay was 6.7 ± 1.6 days. Five patients were medication-free at final follow-up, with no recurrence in any patient. Overlap anastomosis with autonomic nerve-preserved jejunal limb was safe and feasible for laparoscopic distal gastrectomy with lymph node dissection.


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