How Spreading Depolarization Can Be the Pathophysiological Correlate of Both Migraine Aura and Stroke

2014 ◽  
pp. 137-140 ◽  
Author(s):  
Jens P. Dreier ◽  
◽  
Clemens Reiffurth ◽  
Johannes Woitzik ◽  
Jed A. Hartings ◽  
...  
Keyword(s):  
Migraine Aura ◽  
Spreading Depolarization

scholarly journals Glucose Modulation of Spreading Depression Susceptibility

2012 ◽  
Vol 33 (2) ◽  
pp. 191-195 ◽  
Author(s):  
Ulrike Hoffmann ◽  
Inna Sukhotinsky ◽  
Katharina Eikermann-Haerter ◽  
Cenk Ayata
Keyword(s):  
Blood Glucose ◽  
Spreading Depression ◽  
Propagation Speed ◽  
Migraine Aura ◽  
Potential Therapeutic Target ◽  
Physiological Factors ◽  
Spreading Depolarization ◽  
Intensity Threshold ◽  
Cortical Electrical Stimulation ◽  
Dextrose Infusion

Spreading depression of Leão is an intense spreading depolarization (SD) wave associated with massive transmembrane ionic, water, and neurotransmitter shifts. Spreading depolarization underlies migraine aura, and occurs in brain injury, making it a potential therapeutic target. While susceptibility to SD can be modulated pharmacologically, much less is known about modulation by systemic physiological factors, such as the glycemic state. In this study, we systematically examined modulation of SD susceptibility by blood glucose in anesthetized rats under full physiological monitoring. Hyperglycemia and hypoglycemia were induced by insulin or dextrose infusion (blood glucose ~40 and 400 mg/dL, respectively). Spreading depolarizations were evoked by direct cortical electrical stimulation to determine the intensity threshold, or by continuous topical KCl application to determine SD frequency. Hyperglycemia elevated the electrical SD threshold and reduced the frequency of KCl-induced SDs, without significantly affecting other SD properties. In contrast, hypoglycemia significantly prolonged individual and cumulative SD durations, but did not alter the electrical SD threshold, or SD frequency, amplitude or propagation speed. These data show that increased cerebral glucose availability makes the tissue resistant to SD.

Spreading depolarization, a pathophysiological mechanism of stroke and migraine aura

2012 ◽  
Vol 7 (1) ◽  
pp. 45-64 ◽  
Author(s):  
Ana I Oliveira-Ferreira ◽  
Maren KL Winkler ◽  
Clemens Reiffurth ◽  
Denny Milakara ◽  
Johannes Woitzik ◽  
...  
Keyword(s):  
Pathophysiological Mechanism ◽  
Migraine Aura ◽  
Spreading Depolarization

Midlife Migraine/Aura Linked With Late-Life Brain Infarcts

2007 ◽  
Vol 40 (23) ◽  
pp. 13
Author(s):  
DENISE NAPOLI
Keyword(s):  
Late Life ◽  
Migraine Aura ◽  
Brain Infarcts

Cortical spreading depolarization and ketamine: a short systematic review

2021 ◽  
Author(s):  
João Paulo Mota Telles ◽  
Leonardo Christiaan Welling ◽  
Antonio Carlos Samaia da Silva Coelho ◽  
Nícollas Nunes Rabelo ◽  
Manoel Jacobsen Teixeira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Spreading Depolarization

scholarly journals Widespread brain parenchymal HMGB1 and NF-κB neuroinflammatory responses upon cortical spreading depolarization in familial hemiplegic migraine type 1 mice

2021 ◽  
pp. 105424
Author(s):  
Anisa Dehghani ◽  
Thas Phisonkunkasem ◽  
Sinem Yilmaz Ozcan ◽  
Turgay Dalkara ◽  
Arn M.J.M. van den Maagdenberg ◽  
...  
Keyword(s):  
Familial Hemiplegic Migraine ◽  
Hemiplegic Migraine ◽  
Spreading Depolarization ◽  
Brain Parenchymal

Prolonged Migraine Stuttering Aura: Structural, Functional, and Video Neuroimaging Study of an Atypical Migraine Aura. A Case Report

2020 ◽  
Vol 60 (4) ◽  
pp. 776-780
Author(s):  
Emilio Rodríguez‐Castro ◽  
Ariela N. Lagorio ◽  
Alejandro Bejarano‐García ◽  
Pablo Aguiar ◽  
Julia Cortés ◽  
...  
Keyword(s):  
Case Report ◽  
Migraine Aura ◽  
Neuroimaging Study
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