PRESS-PLOT: An Online Server for Protein Structural Analysis and Evaluation with Residue-level Virtual Angle Correlation Plots

2015 ◽  
pp. 150-161
Author(s):  
Yuanyuan Huang ◽  
Kejue Jia ◽  
Robert Jernigan ◽  
Zhijun Wu
Keyword(s):  
Structural Analysis ◽  
Residue Level ◽  
Analysis And Evaluation ◽  
Protein Structural Analysis

Preparative separation, structural analysis and evaluation of dentin stiffening activity of grape seed oligomeric proanthocyanidins

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
RS Phansalkar ◽  
SN Chen ◽  
J Napolitano ◽  
JW Nam ◽  
JB Mc Alpine ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Grape Seed ◽  
Preparative Separation ◽  
Analysis And Evaluation ◽  
Oligomeric Proanthocyanidins

scholarly journals Vaccine candidate P6 of nontypable Haemophilus influenzae is not a transmembrane protein based on protein structural analysis

Vaccine ◽  
2011 ◽  
Vol 29 (8) ◽  
pp. 1624-1627 ◽  
Author(s):  
Lea Vacca Michel ◽  
Breanna Kalmeta ◽  
Mark McCreary ◽  
Joy Snyder ◽  
Paul Craig ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Haemophilus Influenzae ◽  
Vaccine Candidate ◽  
Transmembrane Protein ◽  
Protein Structural Analysis

scholarly journals Structural analysis and evaluation of actual PC bridge using 950 keV/3.95 MeV X-band linacs

2017 ◽  
Vol 874 ◽  
pp. 012105 ◽  
Author(s):  
H Takeuchi ◽  
R Yano ◽  
I Ozawa ◽  
Y Mitsuya ◽  
K Dobashi ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Analysis And Evaluation ◽  
X Band

scholarly journals Integrating population variation and protein structural analysis to improve the clinical genetic diagnosis and treatment in children with congenital nephrogenic diabetes insipidus

2020 ◽  
Author(s):  
Panli LIAO ◽  
Tianchao XIANG ◽  
Hongxia LI ◽  
Ye FANG ◽  
Xiaoyan FANG ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Diabetes Insipidus ◽  
Nephrogenic Diabetes Insipidus ◽  
Genetic Disorder ◽  
Genetic Diagnosis ◽  
Isotonic Saline ◽  
Population Variation ◽  
Pathogenic Mutations ◽  
Protein Structural Analysis ◽  
Congenital Nephrogenic Diabetes Insipidus

Abstract Background and Objectives: Congenital nephrogenic diabetes insipidus (NDI) is a rare genetic disorder characterized by renal inability to concentrate urine. Establishing the genetic diagnosis appears particularly important to NDI for early detection and differential diagnosis.Method: We utilized a Chinese multicenter registry to investigate genotype and phenotype in children with NDI from 2014 to 2019. The structural locations of the pathogenic mutations from this study and the literature, as well as population variants retried from gnomAD were analyzed. Results: A total of 10 boys from 9 families carried mutations in AVPR2 (8/10) or AQP2 (2/10). Another 7 relatives of the families were diagnosed by sequencing for partial or subclinical NDI. Patients presented with dehydration, polyuria-polydipsia, and severe hypernatremia with a median age at diagnosis of 1.0 month (IQR 0.16, 18). Protein structural analysis revealed a notable clustering of diagnostic mutations in the transmembrane regions of AVPR2, and enrichment of diagnostic mutations by autosomal dominant inheritance (AD) in the C terminal region of AQP2. The pathogenic mutations are significantly more likely to be buried inside the domain comparing the population variants. Through structural analysis and in silico prediction, the eight mutations identified in this study were considered as presumably disease causative. The most common treatments were thiazide diuretics and non-steroidal anti-inflammatory drugs (NSAIDs). Emergency treatment of hypernatremic dehydration in neonates should not choose the isotonic saline as a rehydration fluid.Conclusion: Genetic analysis presumably confirmed the diagnosis of NDI in every patient of the studied cohort. A plea of early identifying NDI confirmed by phenotype and genotype, and consequently optimize the treatment.

4-Methylpseudoproline analogues of cyclolinopeptide A: Synthesis, structural analysis and evaluation of their suppressive effects in selected immunological assays

Peptides ◽  
2020 ◽  
Vol 132 ◽  
pp. 170365
Author(s):  
Joanna Katarzyńska ◽  
Jolanta Artym ◽  
Iwona Kochanowska ◽  
Karol Jędrzejczak ◽  
Michał Zimecki ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Analysis And Evaluation ◽  
Immunological Assays

Structural analysis and evaluation of the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) gene in human essential hypertension

1998 ◽  
Vol 16 (11) ◽  
pp. 1627-1633 ◽  
Author(s):  
Eva Brand ◽  
Norihiro Kato ◽  
Nathalie Chatelain ◽  
Zygmunt S. Krozowski ◽  
Xavier Jeunemaitre ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Structural Analysis ◽  
Hydroxysteroid Dehydrogenase ◽  
Analysis And Evaluation
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