Sustainable development goal 2 aims to “end hunger, achieve food security and improved nutrition, and promote sustainable agriculture.” SDG2 is one of the most challenging goals to achieve, as it needs to be achieved within the constraints of the multiple demands agriculture faces. The goal of this chapter is to discuss the roles that science, technology, and innovation (STI) can play in optimal nitrogen management as a way to meet sustainable development goal 2. Optimal nitrogen management will enhance food security by improving yields, and it will promote sustainable agriculture by limiting environmental externalities associated with nitrogen. Specifically, this chapter aims to address the following two questions: 1) How can new technologies help boost agricultural productivity while also reducing nitrogen pollution? And, 2) What policy and institutional changes will be needed to encourage innovation and diffusion of these technologies in developing countries? The authors present STI possibilities for improved nitrogen management in the following categories: new types of nitrogen fertilizers, integrated soil and fertility management technologies, precision agriculture technologies, technologies aiding biological nitrogen fixation, and biotechnology solutions. The chapter ends with a discussion of institutional and policy changes needed for widespread adoption of the technology options among resource-poor smallholder farmers.