Existence of nonoscillatory solutions for the second-order dynamic equation(A0xΔ)Δ(t)+∑i∈[1,n]ℕAi(t)x(αi(t))=0fort∈[t0,∞)Tis investigated in this paper. The results involve nonoscillation criteria in terms of relevant dynamic and generalized characteristic inequalities, comparison theorems, and explicit nonoscillation and oscillation conditions. This allows to obtain most known nonoscillation results for second-order delay differential equations in the caseA0(t)≡1fort∈[t0,∞)Rand for second-order nondelay difference equations (αi(t)=t+1fort∈[t0,∞)N). Moreover, the general results imply new nonoscillation tests for delay differential equations with arbitraryA0and for second-order delay difference equations. Known nonoscillation results for quantum scales can also be deduced.