The Role of Pulmonary Rehabilitation and Supplemental Oxygen Therapy in the Treatment of Patients with Idiopathic Pulmonary Fibrosis

2018 ◽  
pp. 389-399
Author(s):  
Catherine Wittman ◽  
Jeffrey J. Swigris
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Pulmonary Rehabilitation ◽  
Oxygen Therapy ◽  
Supplemental Oxygen ◽  
Supplemental Oxygen Therapy

scholarly journals Effects of Oxygen on Exercise Duration in Chronic Obstructive Pulmonary Disease Patients before and after Pulmonary Rehabilitation

2010 ◽  
Vol 17 (1) ◽  
pp. e14-e19 ◽  
Author(s):  
Nha Voduc ◽  
Caroline Tessier ◽  
Elham Sabri ◽  
Dean Fergusson ◽  
Lyne Lavallee ◽  
...  
Keyword(s):  
Pulmonary Rehabilitation ◽  
Oxygen Therapy ◽  
Exercise Duration ◽  
Supplemental Oxygen ◽  
Rehabilitation Program ◽  
Chronic Obstructive ◽  
Exercise Tests ◽  
Before And After ◽  
Supplemental Oxygen Therapy ◽  
Pulmonary Rehabilitation Program

BACKGROUND: Supplemental oxygen therapy has been shown to improve exercise performance in patients with chronic obstructive pulmonary disease (COPD). It is unknown whether the magnitude of this benefit would be affected by participation in a pulmonary rehabilitation program.OBJECTIVE: To compare the effects of supplemental oxygen on exercise capacity in nonhypoxemic COPD patients before and after participation in a pulmonary rehabilitation program.METHODS: Sixteen patients with COPD underwent two pairs of constant-load exercise tests before and after participation in a three-month outpatient pulmonary rehabilitation program. Each pair of exercise tests consisted of a test performed with room air and a second test performed with 50% supplemental oxygen, in random order. The primary outcome was the difference in exercise duration between tests performed with supplemental oxygen and with room air. This difference was compared before and after participation in a pulmonary rehabilitation program.RESULTS: Supplemental oxygen therapy improved exercise duration by 75 s before participation in a pulmonary rehabilitation program and by 153 s following pulmonary rehabilitation. Rehabilitation alone improved exercise duration by 28 s, but rehabilitation appeared to augment the exercise benefits of supplemental oxygen therapy by a mean of 78 s (95% CI 11 s to 145 s; P=0.03).CONCLUSION: The effects of supplemental oxygen therapy were augmented after pulmonary rehabilitation. The improvement in exercise duration with supplemental oxygen following rehabilitation was greater than either supplemental oxygen or pulmonary rehabilitation alone.

scholarly journals Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Diana Badenes-Bonet ◽  
Pilar Cejudo ◽  
Anna Rodó-Pin ◽  
Clara Martín-Ontiyuelo ◽  
Roberto Chalela ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Oxygen Saturation ◽  
Exercise Capacity ◽  
Oxygen Therapy ◽  
Supplemental Oxygen ◽  
Cardiopulmonary Exercise Test ◽  
High Flow ◽  
Rehabilitation Programs ◽  
High Flow Oxygen

Abstract Background Supplemental oxygen delivered with standard oxygen therapy (SOT) improves exercise capacity in patients with idiopathic pulmonary fibrosis (IPF). Although high-flow nasal cannula oxygen therapy (HFNC) improves oxygenation in other respiratory diseases, its impact on exercise performance has never been evaluated in IPF patients. We hypothesized that HFNC may improve exercise capacity in IPF subjects compared to SOT. Methods This was a prospective, crossover, pilot randomized trial that compared both oxygenation methods during a constant submaximal cardiopulmonary exercise test (CPET) in IPF patients with exertional oxygen saturation (SpO2) ≤ 85% in the 6-min walking test. The primary outcome was endurance time (Tlim). Secondary outcomes were muscle oxygen saturation (StO2) and respiratory and leg symptoms. Results Ten IPF patients [71.7 (6) years old, 90% males] were included. FVC and DLCO were 58 ± 11% and 31 ± 13% pred. respectively. Tlim during CPET was significantly greater using HFNC compared to SOT [494 ± 173 vs. 381 ± 137 s, p = 0.01]. HFNC also associated with a higher increase in inspiratory capacity (IC) [19.4 ± 14.2 vs. 7.1 ± 8.9%, respectively; p = 0.04], and a similar trend was observed in StO2 during exercise. No differences were found in respiratory or leg symptoms between the two oxygen devices. Conclusions This is the first study demonstrating that HFNC oxygen therapy improves exercise tolerance better than SOT in IPF patients with exertional desaturation. This might be explained by changes in ventilatory mechanics and muscle oxygenation. Further and larger studies are needed to confirm the benefits of HFNC in IPF patients and its potential usefulness in rehabilitation programs.

Role of Wnt/PCP pathway on bronchial cell function in Idiopathic Pulmonary Fibrosis

Pneumologie ◽  
2011 ◽  
Vol 65 (12) ◽  
Author(s):  
S Barkha ◽  
M Gegg ◽  
H Lickert ◽  
M Königshoff
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Cell Function

Role of Bcl-xL in hepatocyte growth factor-elicited epithelial protection in idiopathic pulmonary fibrosis

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
S Skwarna ◽  
I Henneke ◽  
W Seeger ◽  
T Geiser ◽  
A Günther ◽  
...  
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth

Supplemental oxygen therapy in trauma patients: an exploratory registry‐based study

2021 ◽  
Author(s):  
Mathias A. Christensen ◽  
Jacob Steinmetz ◽  
George Velmahos ◽  
Lars S. Rasmussen
Keyword(s):  
Oxygen Therapy ◽  
Supplemental Oxygen ◽  
Trauma Patients ◽  
Supplemental Oxygen Therapy

Defining Hazards of Supplemental Oxygen Therapy in Neonatology Using the FMEA Tool

2013 ◽  
Vol 38 (4) ◽  
pp. 221-228 ◽  
Author(s):  
Anne Catherine van der Eijk ◽  
Denise Rook ◽  
Jenny Dankelman ◽  
Bert Johan Smit
Keyword(s):  
Oxygen Therapy ◽  
Supplemental Oxygen ◽  
Supplemental Oxygen Therapy
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