Noise-Induced Collective Migration for Neural Crest Cells

2010 ◽  
pp. 155-163
Author(s):  
Masataka Yamao ◽  
Honda Naoki ◽  
Shin Ishii
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Collective Migration

scholarly journals Control of the collective migration of enteric neural crest cells by the Complement anaphylatoxin C3a and N-cadherin

2016 ◽  
Vol 414 (1) ◽  
pp. 85-99 ◽  
Author(s):  
Florence Broders-Bondon ◽  
Perrine Paul-Gilloteaux ◽  
Elodie Gazquez ◽  
Julie Heysch ◽  
Matthieu Piel ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Collective Migration ◽  
Anaphylatoxin C3a

scholarly journals A Rho-GTPase based model explains spontaneous collective migration of neural crest cell clusters

2017 ◽  
Author(s):  
Brian Merchant ◽  
Leah Edelstein-Keshet ◽  
James J. Feng
Keyword(s):  
Neural Crest ◽  
Rho Gtpase ◽  
Neural Crest Cell ◽  
Reaction Diffusion ◽  
Neural Crest Cells ◽  
Contact Inhibition ◽  
Reaction Diffusion Equations ◽  
Collective Migration ◽  
Dynamical Interaction ◽  
Cell Clusters

AbstractWe propose a model to explain the spontaneous collective migration of neural crest cells in the absence of an external gradient of chemoattractants. The model is based on the dynamical interaction between Rac1 and RhoA that is known to regulate the polarization, contact inhibition and co-attraction of neural crest cells. Coupling the reaction-diffusion equations for active and inactive Rac1 and RhoA on the cell membrane with a mechanical model for the overdamped motion of membrane vertices, we show that co-attraction and contact inhibition cooperate to produce persistence of polarity in a cluster of neural crest cells by suppressing the random onset of Rac1 hotspots that may mature into new protrusion fronts. This produces persistent directional migration of cell clusters in corridors. Our model confirms a prior hypothesis that co-attraction and contact inhibition are key to spontaneous collective migration, and provides an explanation of their cooperative working mechanism in terms of Rho GTPase signaling. The model shows that the spontaneous migration is more robust for larger clusters, and is most efficient in a corridor of optimal confinement.

scholarly journals In vivo confinement promotes collective migration of neural crest cells

2016 ◽  
Vol 213 (5) ◽  
pp. 543-555 ◽  
Author(s):  
András Szabó ◽  
Manuela Melchionda ◽  
Giancarlo Nastasi ◽  
Mae L. Woods ◽  
Salvatore Campo ◽  
...  
Keyword(s):  
Cell Migration ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Optimal Number ◽  
Collective Cell Migration ◽  
Collective Migration ◽  
Extracellular Matrix Molecule ◽  
Experimental Approaches

Collective cell migration is fundamental throughout development and in many diseases. Spatial confinement using micropatterns has been shown to promote collective cell migration in vitro, but its effect in vivo remains unclear. Combining computational and experimental approaches, we show that the in vivo collective migration of neural crest cells (NCCs) depends on such confinement. We demonstrate that confinement may be imposed by the spatiotemporal distribution of a nonpermissive substrate provided by versican, an extracellular matrix molecule previously proposed to have contrasting roles: barrier or promoter of NCC migration. We resolve the controversy by demonstrating that versican works as an inhibitor of NCC migration and also acts as a guiding cue by forming exclusionary boundaries. Our model predicts an optimal number of cells in a given confinement width to allow for directional migration. This optimum coincides with the width of neural crest migratory streams analyzed across different species, proposing an explanation for the highly conserved nature of NCC streams during development.

Induction of melanocyte precursors from neural crest cells surrounding the neural tube-like structures developed in vitro using mouse ES cell culture

2007 ◽  
Vol 27 (1) ◽  
pp. 45-52
Author(s):  
Koh-ichi Atoh ◽  
Manae S. Kurokawa ◽  
Hideshi Yoshikawa ◽  
Chieko Masuda ◽  
Erika Takada ◽  
...  
Keyword(s):  
Cell Culture ◽  
Neural Crest ◽  
Neural Tube ◽  
Neural Crest Cells ◽  
Es Cell ◽  
Mouse Es Cell
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