scholarly journals Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins

2013 ◽  
pp. 83-104 ◽  
Author(s):  
Jason S. McLellan ◽  
William C. Ray ◽  
Mark E. Peeples
Keyword(s):  
Respiratory Syncytial Virus ◽  
Structure And Function ◽  
Virus Surface ◽  
Syncytial Virus ◽  
And Function ◽  
Surface Glycoproteins

Human respiratory syncytial virus surface glycoproteins F, G and SH form an oligomeric complex

2001 ◽  
Vol 146 (12) ◽  
pp. 2369-2383 ◽  
Author(s):  
S. A. Feldman ◽  
R. L. Crim ◽  
S. A. Audet ◽  
J. A. Beeler
Keyword(s):  
Respiratory Syncytial Virus ◽  
Human Respiratory Syncytial Virus ◽  
Virus Surface ◽  
Oligomeric Complex ◽  
Syncytial Virus ◽  
Surface Glycoproteins

scholarly journals Evaluation of the role of respiratory syncytial virus surface glycoproteins F and G on viral stability and replication: implications for future vaccine design

2019 ◽  
Vol 100 (7) ◽  
pp. 1112-1122 ◽  
Author(s):  
Darby M. DeFord ◽  
Jenna M. Nosek ◽  
Katelyn R. Castiglia ◽  
Emily F. Hasik ◽  
Megan E. Franke ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Vaccine Design ◽  
Virus Surface ◽  
Syncytial Virus ◽  
Surface Glycoproteins

scholarly journals Respiratory Syncytial Virus Infection Disrupts Monolayer Integrity and Function in Cystic Fibrosis Airway Cells

Viruses ◽  
2013 ◽  
Vol 5 (9) ◽  
pp. 2260-2271 ◽  
Author(s):  
Michele Kong ◽  
Patrick Maeng ◽  
Jeong Hong ◽  
Rhonda Szczesniak ◽  
Eric Sorscher ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Cystic Fibrosis Airway ◽  
Syncytial Virus ◽  
And Function ◽  
Airway Cells

scholarly journals Features of the Human Antibody Response against the Respiratory Syncytial Virus Surface Glycoprotein G

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 337
Author(s):  
Kristina Borochova ◽  
Katarzyna Niespodziana ◽  
Katarina Stenberg Hammar ◽  
Marianne van Hage ◽  
Gunilla Hedlin ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Surface Glycoprotein ◽  
Trigger Factor ◽  
Human Antibody ◽  
Th2 Response ◽  
Virus Surface ◽  
Virus Attachment ◽  
Peptide Epitopes ◽  
Glycoprotein G ◽  
Syncytial Virus

Respiratory syncytial virus (RSV) infections are a major cause of serious respiratory disease in infants. RSV occurs as two major subgroups A and B, which mainly differ regarding the surface glycoprotein G. The G protein is important for virus attachment and G-specific antibodies can protect against infection. We expressed the surface-exposed part of A2 strain-derived G (A2-G) in baculovirus-infected insect cells and synthesized overlapping peptides spanning complete A2-G. The investigation of the natural IgG response of adult subjects during a period of one year showed that IgG antibodies (i) recognize G significantly stronger than the fusion protein F0, (ii) target mainly non-conformational, sequential peptide epitopes from the exposed conserved region but also buried peptides, and (iii) exhibit a scattered but constant recognition profile during the observation period. The IgG subclass reactivity profile (IgG1 > IgG2 > IgG4 = IgG3) was indicative of a mixed Th1/Th2 response. Two strongly RSV-neutralizing sera including the 1st WHO standard contained high IgG anti-G levels. G-specific IgG increased strongly in children after wheezing attacks suggesting RSV as trigger factor. Our study shows that RSV G and G-derived peptides are useful for serological diagnosis of RSV-triggered exacerbations of respiratory diseases and underlines the importance of G for development of RSV-neutralizing vaccines.

Evaluation in chimpanzees of vaccinia virus recombinants that express the surface glycoproteins of human respiratory syncytial virus

Vaccine ◽  
1990 ◽  
Vol 8 (2) ◽  
pp. 164-168 ◽  
Author(s):  
Peter L. Collins ◽  
Robert H. Purcell ◽  
William T. London ◽  
Lisa A. Lawrence ◽  
Robert M. Chanock ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Vaccinia Virus ◽  
Human Respiratory Syncytial Virus ◽  
Syncytial Virus ◽  
Surface Glycoproteins
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