DNA-replication fidelity, mismatch repair and genome instability in cancer cells

1996 ◽  
pp. 163-173 ◽  
Author(s):  
Asad Umar ◽  
Thomas A. Kunkel
Keyword(s):  
Dna Replication ◽  
Cancer Cells ◽  
Mismatch Repair ◽  
Genome Instability ◽  
Replication Fidelity ◽  
Dna Replication Fidelity

scholarly journals Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

PLoS Genetics ◽  
2012 ◽  
Vol 8 (10) ◽  
pp. e1003016 ◽  
Author(s):  
Scott A. Lujan ◽  
Jessica S. Williams ◽  
Zachary F. Pursell ◽  
Amy A. Abdulovic-Cui ◽  
Alan B. Clark ◽  
...  
Keyword(s):  
Dna Replication ◽  
Mismatch Repair ◽  
Replication Fidelity ◽  
Lagging Strand ◽  
Dna Replication Fidelity

Reduction of dNTP levels enhances DNA replication fidelity in vivo

DNA Repair ◽  
2013 ◽  
Vol 12 (4) ◽  
pp. 300-305 ◽  
Author(s):  
Luisa Laureti ◽  
Marjorie Selva ◽  
Julien Dairou ◽  
Ivan Matic
Keyword(s):  
Dna Replication ◽  
Replication Fidelity ◽  
Dna Replication Fidelity

scholarly journals Role of Watson-Crick-Like Mismatches in DNA Replication Fidelity

2017 ◽  
Vol 112 (3) ◽  
pp. 70a
Author(s):  
Eric S. Szymanski ◽  
Isaac J. Kimsey ◽  
Hashim M. Al-Hashimi
Keyword(s):  
Dna Replication ◽  
Replication Fidelity ◽  
Dna Replication Fidelity

scholarly journals DNA replication fidelity and cancer

2010 ◽  
Vol 20 (5) ◽  
pp. 281-293 ◽  
Author(s):  
Bradley D. Preston ◽  
Tina M. Albertson ◽  
Alan J. Herr
Keyword(s):  
Dna Replication ◽  
Replication Fidelity ◽  
Dna Replication Fidelity

scholarly journals The Enhanced DNA Replication Fidelity of a Mutant Herpes Simplex Virus Type 1 DNA Polymerase Is Mediated by an Improved Nucleotide Selectivity and Reduced Mismatch Extension Ability

2008 ◽  
Vol 82 (17) ◽  
pp. 8937-8941 ◽  
Author(s):  
Wang Tian ◽  
Ying T. Hwang ◽  
Charles B. C. Hwang
Keyword(s):  
Herpes Simplex Virus ◽  
Dna Replication ◽  
Herpes Simplex ◽  
Dna Polymerase ◽  
Herpes Simplex Virus Type ◽  
Wild Type ◽  
Replication Fidelity ◽  
Simplex Virus ◽  
Dna Replication Fidelity

ABSTRACT We previously demonstrated that a recombinant herpes simplex virus containing a mutation within the finger domain of DNA polymerase replicated DNA with increased fidelity. In this study, we demonstrate that, compared with wild-type polymerase, the mutant enzyme exhibited improved nucleotide selectivity and a reduced ability to extend from mismatched primer termini, which would contribute to the increased DNA replication fidelity.

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