Effect of Methylpredonisolone on Spinal Cord Blood Flow After Spinal Cord Injury in Rats

1993 ◽  
pp. 440-443
Author(s):  
Hiroyuki Imamura ◽  
Yoshinobu Iwasaki ◽  
Kazutoshi Hida ◽  
Hiroshi Abe
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Blood Flow ◽  
Cord Blood ◽  
Spinal Cord Blood Flow ◽  
Cord Injury

scholarly journals The Effects of Local Cooling on Canine Spinal Cord Blood Flow

1985 ◽  
Vol 12 (2) ◽  
pp. 83-87 ◽  
Author(s):  
Robert R. Hansebout ◽  
R. Neil Lamont ◽  
M. Venkatraya Kamath
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Blood Flow ◽  
Cord Blood ◽  
Normal Values ◽  
Local Cooling ◽  
Spinal Cord Blood Flow ◽  
Central Temperature ◽  
Cord Injury

ABSTRACT:The internal spinal cord blood flow was measured in dogs at the site of local cooling using hydrogen polarography. Blood flow decreased to 50% of the normothermic values during cooling of the cord to a central temperature of 16 degrees Celsius. Upon cessation of cooling internal blood flow rapidly returned to normal values. Implications of this finding for the treatment of spinal cord injury are discussed.

Failure of Naloxone to Improve Spinal Cord Blood Flow and Cardiac Output after Spinal Cord Injury

Neurosurgery ◽  
1986 ◽  
Vol 18 (4) ◽  
pp. 428-432 ◽  
Author(s):  
Christopher M. Wallace ◽  
Charles H. Tator
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Blood Flow ◽  
Cardiac Output ◽  
Cord Blood ◽  
Systemic Arterial Pressure ◽  
Compression Injury ◽  
Spinal Cord Blood Flow ◽  
Progressive Decline ◽  
Cord Injury

Abstract It has been reported that the narcotic antagonist, naloxone, can improve spinal cord blood flow (SCBF) and clinical recovery after experimental spinal cord injury produced by the weight-dropping technique. The purpose of the present study was to determine the effect of naloxone on SCBF, cardiac output (CO) and blood flow to other organs following clip compression injury. Rats were anesthetized, paralyzed and ventilated, with mean systemic arterial pressure (MSAP) recorded continuously, After a C-7-T-1 laminectomy and a 1-minute acute compression injury with a 50-g clip at T-1, rats were given injections of radioactive microspheres for measurement of SCBF, CO, and blood flow to other organs. The first determination was made 15 minutes after injury and a second was made after a 1-hour treatment with naloxone. Treated animals each received an intravenous bolus injection of naloxone (10 mg/kg) followed by a 1-hour intravenous infusion (2 mg/kg/hour). Naloxone failed to improve posttraumatic SCBF in the injured spinal cord. In addition, naloxone did not prevent posttraumatic hypotension or the progressive decline in CO seen between 15 and 75 minutes after injury. Thus, this study does not support the previous claims of a beneficial effect of naloxone on posttraumatic SCBF and MSAP.

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