The Inhibitory Glycine Receptor: Structure-Function Studies on a Neuronal Chloride Channel

1992 ◽  
pp. 233-239
Author(s):  
D. Langosch ◽  
I. Pribilla ◽  
T. Takagi ◽  
K. Hartung ◽  
J. Bormann
Keyword(s):  
Structure Function ◽  
Chloride Channel ◽  
Glycine Receptor ◽  
Receptor Structure

Insulin and its receptor: structure, function and evolution

BioEssays ◽  
2004 ◽  
Vol 26 (12) ◽  
pp. 1351-1362 ◽  
Author(s):  
Pierre De Meyts
Keyword(s):  
Structure Function ◽  
Receptor Structure

scholarly journals The glycine receptor deficiency of the mutant mouse spastic: evidence for normal glycine receptor structure and localization

1986 ◽  
Vol 6 (5) ◽  
pp. 1358-1364 ◽  
Author(s):  
CM Becker ◽  
I Hermans-Borgmeyer ◽  
B Schmitt ◽  
H Betz
Keyword(s):  
Mutant Mouse ◽  
Glycine Receptor ◽  
Receptor Structure

Structure-Function Relationships of the Human Glycine Receptor: Insights from Hyperekplexia Mutations

1999 ◽  
Vol 868 (1 MOLECULAR AND) ◽  
pp. 681-684 ◽  
Author(s):  
TREVOR M. LEWIS ◽  
PETER R. SCHOFIELD
Keyword(s):  
Structure Function ◽  
Glycine Receptor

Acetylcholine Receptor Structure, Function, and Evolution

1985 ◽  
Vol 1 (1) ◽  
pp. 317-351 ◽  
Author(s):  
Robert M. Stroud ◽  
Janet Finer-Moore
Keyword(s):  
Structure Function ◽  
Acetylcholine Receptor ◽  
Receptor Structure

The human androgen receptor: Structure/function relationship in normal and pathological situations

1992 ◽  
Vol 41 (3-8) ◽  
pp. 361-368 ◽  
Author(s):  
A.O. Brinkmann ◽  
G. Jenster ◽  
G.G.J.M. Kuiper ◽  
C. Ris ◽  
J.H. van Laar ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Structure Function ◽  
Receptor Structure ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Human Androgen Receptor

Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes

2002 ◽  
Vol 283 (4) ◽  
pp. G856-G863 ◽  
Author(s):  
Matthias Froh ◽  
Ronald G. Thurman ◽  
Michael D. Wheeler
Keyword(s):  
Spinal Cord ◽  
Kupffer Cells ◽  
Chloride Channel ◽  
Glycine Receptor ◽  
Molecular Evidence ◽  
Dependent Manner ◽  
Neuronal Tissues ◽  
The Central Nervous System ◽  
Receptor Fragment ◽  
Dose Dependent

Recent studies have demonstrated that glycine blunts the response of Kupffer cells to endotoxin. Based on pharmacological evidence, it was hypothesized that Kupffer cells and other macrophages contain a glycine-gated chloride channel similar to the glycine receptor expressed in neuronal tissues. Moreover, glycine stimulates influx of radiolabeled chloride in Kupffer cells in a dose-dependent manner. RT-PCR was used to identify mRNA of both α- and β-subunits of the glycine receptor in rat Kupffer cells, peritoneal neutrophils, and splenic and alveolar macrophages, similar to the sequence generated from rat spinal cord. Importantly, the sequence of the cloned Kupffer cell glycine receptor fragment for the β-subunit was >95% homologous with the receptor from the spinal cord. Membranes of these cells also contain a protein that is immunoreactive with antibodies against the glycine-gated chloride channel. These data demonstrate that Kupffer cells, as well as other macrophages and leukocytes, express mRNA and protein for a glycine-gated chloride channel with both molecular and pharmacological properties similar to the channel expressed in the central nervous system.

scholarly journals Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel

2001 ◽  
Vol 276 (16) ◽  
pp. 12556-12564 ◽  
Author(s):  
Qiang Shan ◽  
Justine L. Haddrill ◽  
Joseph W. Lynch
Keyword(s):  
Chloride Channel ◽  
Glycine Receptor
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