Characterization of Human Monoclonal Antibodies Specific for the Rabies Virus

Author(s):  
Léna Edelman ◽  
Monique Lafon
1990 ◽  
Vol 64 (6) ◽  
pp. 3087-3090 ◽  
Author(s):  
B Dietzschold ◽  
M Gore ◽  
P Casali ◽  
Y Ueki ◽  
C E Rupprecht ◽  
...  

2010 ◽  
Vol 54 (11) ◽  
pp. 673-683 ◽  
Author(s):  
Takashi Matsumoto ◽  
Kentaro Yamada ◽  
Kazuko Noguchi ◽  
Kantou Nakajima ◽  
Kenzo Takada ◽  
...  

2010 ◽  
Vol 155 (8) ◽  
pp. 1187-1192 ◽  
Author(s):  
Yan Jiang ◽  
Yonghuang Luo ◽  
Frank Michel ◽  
Robert J. Hogan ◽  
Ying He ◽  
...  

1994 ◽  
Vol 10 (12) ◽  
pp. 1639-1649 ◽  
Author(s):  
ERIC M.M. van der DONK ◽  
MARTIN SCHUTTEN ◽  
ALBERT D.M.E. OSTERHAUS ◽  
ROGER W.J. van der HEIJDEN

2020 ◽  
Vol 88 (10) ◽  
Author(s):  
Xuyao Jiao ◽  
Sarah Smith ◽  
Gabrielle Stack ◽  
Qi Liang ◽  
Allan Bradley ◽  
...  

ABSTRACT Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5 architecture with two active subunits, the ADP ribosyl transferase PltA and the DNase CdtB, linked to a pentameric B subunit, which is alternatively made of PltB or PltC. Here, we describe the generation and characterization of typhoid toxin-neutralizing human monoclonal antibodies by immunizing genetically engineered mice that have a full set of human immunoglobulin variable region genes. We identified several monoclonal antibodies with strong in vitro and in vivo toxin-neutralizing activity and different mechanisms of toxin neutralization. These antibodies could serve as the basis for the development of novel therapeutic strategies against typhoid fever.


1986 ◽  
Vol 14 (1) ◽  
pp. 9-24 ◽  
Author(s):  
Mark J. Redmond ◽  
Michele Leyritz-Wills ◽  
Larry Winger ◽  
Douglas G. Scraba

1990 ◽  
Vol 27 (4) ◽  
pp. 323-332 ◽  
Author(s):  
Vitalia Dessi ◽  
Berta Sanchez ◽  
Marisa Garzon ◽  
Rosario Magariño ◽  
María Dolores Maldonado ◽  
...  

2007 ◽  
Vol 17 (20) ◽  
pp. 5690-5692 ◽  
Author(s):  
Heyue Zhou ◽  
Bin Zhou ◽  
Hongzheng Ma ◽  
Charlotte Carney ◽  
Kim D. Janda

Sign in / Sign up

Export Citation Format

Share Document