Extracellular activities — purine receptors and pharmacology

1991 ◽  
pp. 69-89
Author(s):  
T. W. Stone ◽  
H. A. Simmonds
Keyword(s):  
Purine Receptors

scholarly journals PURINE RECEPTORS: GPCR STRUCTURE AND AGONIST DESIGN

2004 ◽  
Vol 4 (6) ◽  
pp. 337-347 ◽  
Author(s):  
K. A. Jacobson
Keyword(s):  
Purine Receptors ◽  
Gpcr Structure

scholarly journals Effects of NAD at purine receptors in isolated blood vessels

2014 ◽  
Vol 11 (1) ◽  
pp. 47-57 ◽  
Author(s):  
E. Alefishat ◽  
S. P. H. Alexander ◽  
V. Ralevic
Keyword(s):  
Blood Vessels ◽  
Purine Receptors

scholarly journals Purine receptors and guinea-pig trachea: evidence for a direct action of ATP

1988 ◽  
Vol 95 (3) ◽  
pp. 689-694 ◽  
Author(s):  
Laurence A. Welford ◽  
Wayne H. Anderson
Keyword(s):  
Guinea Pig ◽  
Direct Action ◽  
Purine Receptors

Activation of apical P2U purine receptors permits inhibition of adrenaline-evoked cyclic AMP accumulation in cultured equine sweat gland epithelial cells.

1996 ◽  
Vol 199 (10) ◽  
pp. 2153-2160
Author(s):  
S M Wilson ◽  
S Rakhit ◽  
R Murdoch ◽  
J D Pediani ◽  
H Y Elder ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Cyclic Amp ◽  
G Protein ◽  
G Proteins ◽  
Sweat Gland ◽  
Purine Receptors ◽  
Cyclic Amp Accumulation ◽  
Guanine Nucleotide Binding ◽  
Purinergic Nerves ◽  
Nucleotide Binding Proteins

Experiments were undertaken using cultured equine sweat gland epithelial cells that express purine receptors belonging to the P2U subclass which allow the selective agonist uridine triphosphate (UTP) to increase the concentration of intracellular free Ca2+ ([Ca2+]i). Experiments using pertussis toxin (Ptx), which inactivates certain guanine-nucleotide-binding proteins (G-proteins), showed that this response consisted of Ptx-sensitive and Ptx-resistant components, and immunochemical analyses of the G-protein alpha subunits present in the cells showed that both Ptx-sensitive (alpha i1-3) and Ptx-resistant (alpha q/11) G-proteins were expressed. P2U receptors may, therefore, normally activate both of these G-protein families. Ptx-sensitive, alpha i2/3 subunits permit inhibitory control of adenylate cyclase, and UTP was shown to cause Ptx-sensitive inhibition of adrenaline-evoked cyclic AMP accumulation, suggesting that the receptors activate Gi2/3. Experiments using cells grown on permeable supports suggested that P2U receptors became essentially confined to the apical membrane in post-confluent cultures. Polarised epithelia may, therefore, express apical P2U receptors which influence two centrally important signal transduction pathways. It is highly improbable that these receptors could be activated by nucleotides released from purinergic nerves, but they may be involved in the autocrine regulation of epithelial function.

scholarly journals ATP Released from Low-dose Gamma Ray-irradiated Cells Activates Intracellular Antioxidant Systems via Purine Receptors

2011 ◽  
Vol 8 (7) ◽  
pp. 108-113 ◽  
Author(s):  
Shiuji Kojima ◽  
Erina Takai ◽  
Mitsutoshi Tsukimoto
Keyword(s):  
Low Dose ◽  
Gamma Ray ◽  
Antioxidant Systems ◽  
Purine Receptors

scholarly journals Novel therapeutics acting via purine receptors

1991 ◽  
Vol 41 (10) ◽  
pp. 1399-1410 ◽  
Author(s):  
Kenneth A. Jacobson ◽  
Bharat K. Trivedi ◽  
Paul C. Churchill ◽  
Michael Williams
Keyword(s):  
Purine Receptors ◽  
Novel Therapeutics

Binding of adenosine analogs with type A1 purine receptors in the guinea pig ileum

1990 ◽  
Vol 109 (2) ◽  
pp. 204-206
Author(s):  
G. M. Poltavchenko ◽  
V. F. Katkov ◽  
V. N. Pavlov ◽  
O. V. Travkin
Keyword(s):  
Guinea Pig ◽  
Guinea Pig Ileum ◽  
Purine Receptors ◽  
Adenosine Analogs

scholarly journals Purine receptors are required for DHA-mediated neuroprotection against oxygen and glucose deprivation in hippocampal slices

2014 ◽  
Vol 11 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Simone Molz ◽  
Gislaine Olescowicz ◽  
Jessica Rossana Kraus ◽  
Fabiana Kalyne Ludka ◽  
Carla I. Tasca
Keyword(s):  
Hippocampal Slices ◽  
Glucose Deprivation ◽  
Purine Receptors ◽  
Oxygen And Glucose Deprivation

Purine receptors: classification and properties

1984 ◽  
Vol 5 ◽  
pp. 340-343 ◽  
Author(s):  
David Satchell
Keyword(s):  
Purine Receptors
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