Kinetic Resolution of α-Hydroxy Carboxylic Acid Derivatives Based on Chiral Recognition of Substrate–Cocatalyst Complex

2019 ◽  
pp. 65-103
Author(s):  
Yinli Wang
Keyword(s):  
Carboxylic Acid ◽  
Chiral Recognition ◽  
Kinetic Resolution ◽  
Hydroxy Carboxylic Acid

scholarly journals Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Ming Hu ◽  
Ying-Xue Yuan ◽  
Weizhou Wang ◽  
Dong-Mi Li ◽  
Hong-Chao Zhang ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Theoretical Calculation ◽  
Fluorescence Intensity ◽  
Chiral Recognition ◽  
Natural World ◽  
Enantiomer Excess ◽  
Intensity Changes ◽  
Colour Changes ◽  
Chiral Receptors ◽  
Fluorescence Wavelength

AbstractChiral recognition, such as enantioselective interactions of enzyme with chiral agents, is one of the most important issues in the natural world. But artificial chiral receptors are much less efficient than natural ones. For tackling the chiral recognition and enantiomer excess (ee) analysis, up until now all the fluorescent receptors have been developed based on fluorescence intensity changes. Here we report that the chiral recognition of a large number of chiral carboxylic acids, including chiral agrochemicals 2,4-D, is carried out based on fluorescent colour changes rather than intensity changes of AIEgen rotors. Moreover, the fluorescence wavelength of the AIEgen rotor linearly changes with ee of the carboxylic acid, enabling the ee to be accurately measured with average absolute errors (AAE) of less than 2.8%. Theoretical calculation demonstrates that the wavelength change is ascribed to the rotation of the AIEgen rotor upon interaction with different enantiomers.

Simultaneous “O–Alkyl” and “O–Acyl” Lactone Cleavages from Hydroxy–Carboxylic Acid Initiators: Direct Access to Multiblock Architectures

2019 ◽  
Vol 52 (17) ◽  
pp. 6382-6392 ◽  
Author(s):  
Bryan Raeskinet ◽  
Sébastien Moins ◽  
Luke Harvey ◽  
Julien De Winter ◽  
Céline Henoumont ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Direct Access ◽  
Hydroxy Carboxylic Acid

Chiral Recognition and Kinetic Resolution of Aromatic Amines via Supramolecular Chiral Nanocapsules in Nonpolar Solvents

2013 ◽  
Vol 135 (9) ◽  
pp. 3371-3374 ◽  
Author(s):  
Toshiyuki Kida ◽  
Takuya Iwamoto ◽  
Haruyasu Asahara ◽  
Tomoaki Hinoue ◽  
Mitsuru Akashi
Keyword(s):  
Aromatic Amines ◽  
Chiral Recognition ◽  
Kinetic Resolution ◽  
Nonpolar Solvents

Lipase-catalyzed kinetic and dynamic kinetic resolution of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

2007 ◽  
Vol 18 (12) ◽  
pp. 1428-1433 ◽  
Author(s):  
Tihamér A. Paál ◽  
Enikő Forró ◽  
Arto Liljeblad ◽  
Liisa T. Kanerva ◽  
Ferenc Fülöp
Keyword(s):  
Carboxylic Acid ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

Discovery and characterization of GSK256073, a non-flushing hydroxy-carboxylic acid receptor 2 (HCA2) agonist

2015 ◽  
Vol 756 ◽  
pp. 1-7 ◽  
Author(s):  
Dennis Sprecher ◽  
Miles Maxwell ◽  
Joanne Goodman ◽  
Brian White ◽  
Chi-Man Tang ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Acid Receptor ◽  
Hydroxy Carboxylic Acid
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