Metabolic Control Analysis

2005 ◽  
pp. 69-80 ◽  
Author(s):  
David A. Fell
Keyword(s):  
Metabolic Control ◽  
Metabolic Control Analysis ◽  
Control Analysis

scholarly journals Constraint-based metabolic control analysis for rational strain engineering

2021 ◽  
Author(s):  
Sophia Tsouka ◽  
Meric Ataman ◽  
Tuure Hameri ◽  
Ljubisa Miskovic ◽  
Vassily Hatzimanikatis
Keyword(s):  
Metabolic Control ◽  
Strain Engineering ◽  
Metabolic Control Analysis ◽  
Control Analysis

Advances in metabolic control analysis

1993 ◽  
Vol 9 (3) ◽  
pp. 221-233 ◽  
Author(s):  
James C. Liao ◽  
Javier Delgado
Keyword(s):  
Metabolic Control ◽  
Metabolic Control Analysis ◽  
Control Analysis

scholarly journals Metabolic Engineering des Methylerythritolphosphat-Wegs durch Metabolic Control Analysis

2014 ◽  
Vol 86 (9) ◽  
pp. 1403-1403
Author(s):  
D. Volke ◽  
B. Engels ◽  
L. Wright ◽  
J. Gershenzon ◽  
S. Jennewein
Keyword(s):  
Metabolic Engineering ◽  
Metabolic Control ◽  
Metabolic Control Analysis ◽  
Control Analysis

Application of Metabolic Control Analysis to Photosynthesis: the Problem of Getting Data for an Impressive Algorithm

1990 ◽  
pp. 351-361 ◽  
Author(s):  
Christoph Giersch ◽  
Dirk Lämmel ◽  
Klaus Steffen
Keyword(s):  
Metabolic Control ◽  
Metabolic Control Analysis ◽  
Control Analysis

Metabolic control analysis of an enzymatic biofuel cell

2009 ◽  
Vol 102 (6) ◽  
pp. 1624-1635 ◽  
Author(s):  
Doris J. Glykys ◽  
Scott Banta
Keyword(s):  
Metabolic Control ◽  
Metabolic Control Analysis ◽  
Biofuel Cell ◽  
Control Analysis ◽  
Enzymatic Biofuel Cell

Top Down Metabolic Control Analysis of Oxidative Phosphorylation at Different Rates in Potato Tuber Mitochondria

1993 ◽  
pp. 333-338
Author(s):  
Adolf Kesseler ◽  
Philippe Diolez ◽  
Klaus Brinkmann ◽  
Martin D. Brand
Keyword(s):  
Oxidative Phosphorylation ◽  
Potato Tuber ◽  
Metabolic Control ◽  
Metabolic Control Analysis ◽  
Control Analysis ◽  
Top Down

scholarly journals Constraint-based metabolic control analysis for rational strain engineering

2020 ◽  
Author(s):  
Sophia Tsouka ◽  
Meric Ataman ◽  
Tuure Hameri ◽  
Ljubisa Miskovic ◽  
Vassily Hatzimanikatis
Keyword(s):  
Metabolic Engineering ◽  
Genome Editing ◽  
Metabolic Control ◽  
Metabolic Flux ◽  
Strain Engineering ◽  
Metabolic Control Analysis ◽  
Physiological Data ◽  
Response Analysis ◽  
Control Analysis ◽  
Wide Range

AbstractThe advancements in genome editing techniques over the past years have rekindled interest in rational metabolic engineering strategies. While Metabolic Control Analysis (MCA) is a well-established method for quantifying the effects of metabolic engineering interventions on flows in metabolic networks and metabolic concentrations, it fails to account for the physiological limitations of the cellular environment and metabolic engineering design constraints. We report here a constraint-based framework based on MCA, Network Response Analysis (NRA), for the rational genetic strain design that incorporates biologically relevant constraints, as well as genome editing restrictions. The NRA core constraints being similar to the ones of Flux Balance Analysis, allow it to be used for a wide range of optimization criteria and with various physiological constraints. We show how the parametrization and introduction of biological constraints enhance the NRA formulation compared to the classical MCA approach, and we demonstrate its features and its ability to generate multiple alternative optimal strategies given several user-defined boundaries and objectives. In summary, NRA is a sophisticated alternative to classical MCA for rational metabolic engineering that accommodates the incorporation of physiological data at metabolic flux, metabolite concentration, and enzyme expression levels.

Metabolic Control Analysis: Separable Matrices and Interdependence of Control Coefficients

1998 ◽  
Vol 193 (4) ◽  
pp. 649-661 ◽  
Author(s):  
Ludwig Elsner ◽  
Christoph Giersch
Keyword(s):  
Metabolic Control ◽  
Metabolic Control Analysis ◽  
Control Analysis ◽  
Control Coefficients

scholarly journals S7.11 Metabolic control analysis of bioenergetic function in synaptosomes

2008 ◽  
Vol 1777 ◽  
pp. S47
Author(s):  
Jayne Telford ◽  
Michael J. Rowan ◽  
Keith F. Tipton ◽  
Martha Motherway Gildea ◽  
Gavin P. Davey
Keyword(s):  
Metabolic Control ◽  
Metabolic Control Analysis ◽  
Control Analysis
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