Structural organization of de novo purine biosynthesis enzymes in plants: 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase cDNAs from Vigna aconitifolia

1994 ◽  
Vol 24 (2) ◽  
pp. 389-395 ◽  
Author(s):  
Kenneth A. Chapman ◽  
Ashton J. Delauney ◽  
Jong H. Kim ◽  
Desh Pal S. Verma
Keyword(s):  
Structural Organization ◽  
De Novo ◽  
Purine Biosynthesis ◽  
Vigna Aconitifolia ◽  
De Novo Purine Biosynthesis

scholarly journals Carbocyclic substrates for de novo purine biosynthesis.

1991 ◽  
Vol 266 (25) ◽  
pp. 16699-16702
Author(s):  
D.S. Liu ◽  
C.A. Caperelli
Keyword(s):  
De Novo ◽  
Purine Biosynthesis ◽  
De Novo Purine Biosynthesis

Purine metabolism in Neisseria gonorrhoeae: the requirement for hypoxanthine

1980 ◽  
Vol 26 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Stephen A. Morse ◽  
Lynne Bartenstein
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Growth Medium ◽  
De Novo ◽  
Defined Medium ◽  
Purine Metabolism ◽  
Purine Biosynthesis ◽  
Free Medium ◽  
De Novo Purine Biosynthesis ◽  
Reduced Rate

Strains isolated from disseminated gonococcal infections often require hypoxanthine for growth. The biochemical bases for the requirement for hypoxanthine in strains isolated from both disseminated (Ile−Val−Arg−Hyx−Ura−phenotype) and non-disseminated (Hyx−phenotype) infections were compared. The requirement for hypoxanthine was dependent upon the composition of the growth medium. In a complete defined medium, hypoxanthine was replaced by a mixture of adenine and guanine but not by either purine alone. The addition of adenine alone inhibited gonococcal growth. This inhibition was reversed by the addition of guanine and most likely resulted from an inhibition of de novo purine biosynthesis. In a histidine-free medium, adenine replaced the hypoxanthine requirement in Ile−Val−Arg−Hyx−Ura− strains. Adenine did not replace the hypoxanthine requirement in Hyx− strains. The Ile−Val−Arg−Hyx−Ura− strains exhibited a markedly reduced rate of de novo purine biosynthesis while Hyx− strains were blocked in this pathway. In vivo concentrations of purines are important factors which may limit the intracellular or extracellular growth of these strains.

scholarly journals Regulation of de Novo Purine Biosynthesis by Methenyltetrahydrofolate Synthetase in Neuroblastoma

2006 ◽  
Vol 281 (7) ◽  
pp. 4215-4221 ◽  
Author(s):  
Martha S. Field ◽  
Doletha M.E. Szebenyi ◽  
Patrick J. Stover
Keyword(s):  
De Novo ◽  
Purine Biosynthesis ◽  
De Novo Purine Biosynthesis ◽  
Methenyltetrahydrofolate Synthetase
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