Production and characterization of a monoclonal antibody against human calcitonin gene-related peptide (CGRP) and its immunohistochemical application to salivary glands

1994 ◽  
Vol 26 (4) ◽  
pp. 317-326 ◽  
Author(s):  
Ewa Szabat ◽  
Antero Salo ◽  
Ismo Virtanen ◽  
Hannu Uusitalo ◽  
Seppo Soinila
Keyword(s):  
Monoclonal Antibody ◽  
Salivary Glands ◽  
Calcitonin Gene Related Peptide ◽  
Human Calcitonin ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor*

2020 ◽  
pp. jpet.119.261065 ◽  
Author(s):  
Eric Moore ◽  
Mark E. Fraley ◽  
Ian M. Bell ◽  
Christopher S. Burgey ◽  
Rebecca B. White ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Human Calcitonin ◽  
Peptide Receptor ◽  
Selective Antagonist ◽  
Related Peptide ◽  
Calcitonin Gene

Characterization of the Human Calcitonin Gene-Related Peptide Receptor Subtypes Associated with Receptor Activity-Modifying Proteins

2004 ◽  
Vol 65 (1) ◽  
pp. 207-213 ◽  
Author(s):  
Kenji Kuwasako ◽  
Yuan-Ning Cao ◽  
Yasuko Nagoshi ◽  
Toshihiro Tsuruda ◽  
Kazuo Kitamura ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Receptor Activity ◽  
Receptor Subtypes ◽  
Human Calcitonin ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Receptor Activity Modifying Proteins

Isolation and characterization of human calcitonin gene-related peptide

Nature ◽  
1984 ◽  
Vol 308 (5961) ◽  
pp. 746-748 ◽  
Author(s):  
Howard R. Morris ◽  
Maria Panico ◽  
Tony Etienne ◽  
John Tippins ◽  
Samia I. Girgis ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Human Calcitonin ◽  
Related Peptide ◽  
Isolation And Characterization ◽  
Calcitonin Gene

scholarly journals Pharmacologic Characterization of ALD403, a Potent Neutralizing Humanized Monoclonal Antibody Against the Calcitonin Gene-Related Peptide

2020 ◽  
Vol 374 (1) ◽  
pp. 93-103
Author(s):  
Leon F. Garcia-Martinez ◽  
Carol J. Raport ◽  
Ethan W. Ojala ◽  
Benjamin Dutzar ◽  
Katie Anderson ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Humanized Monoclonal Antibody ◽  
Calcitonin Gene

Galcanezumab for the prevention of migraine

2020 ◽  
Author(s):  
Lindsay M Frerichs ◽  
Deborah I Friedman
Keyword(s):  
Monoclonal Antibody ◽  
Clinical Efficacy ◽  
Preventive Treatment ◽  
Calcitonin Gene Related Peptide ◽  
Efficacy And Safety ◽  
Related Peptide ◽  
Calcitonin Gene

Migraine is a common and disabling disorder affecting approximately 1.02 billion people worldwide. Calcitonin gene-related peptide (CGRP) has been identified as playing an important role in the pathophysiology of migraine and several migraine-specific therapies targeting the CGRP ligand or its receptor have been approved since 2018 for the acute and preventive treatment of migraine. This review focuses on the pharmacology, clinical efficacy and safety/tolerability of galcanezumab, an anti-CGRP monoclonal antibody approved for the prevention of migraine.

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