Characterization of the human calcitonin-gene-related peptide receptor

1987 ◽  
Vol 15 (4) ◽  
pp. 714-715 ◽  
Author(s):  
STEVEN M. FOORD ◽  
ROGER K. CRAIG
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Human Calcitonin ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor*

2020 ◽  
pp. jpet.119.261065 ◽  
Author(s):  
Eric Moore ◽  
Mark E. Fraley ◽  
Ian M. Bell ◽  
Christopher S. Burgey ◽  
Rebecca B. White ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Human Calcitonin ◽  
Peptide Receptor ◽  
Selective Antagonist ◽  
Related Peptide ◽  
Calcitonin Gene

Characterization of the Human Calcitonin Gene-Related Peptide Receptor Subtypes Associated with Receptor Activity-Modifying Proteins

2004 ◽  
Vol 65 (1) ◽  
pp. 207-213 ◽  
Author(s):  
Kenji Kuwasako ◽  
Yuan-Ning Cao ◽  
Yasuko Nagoshi ◽  
Toshihiro Tsuruda ◽  
Kazuo Kitamura ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Receptor Activity ◽  
Receptor Subtypes ◽  
Human Calcitonin ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Receptor Activity Modifying Proteins

scholarly journals Characterization of the effects of calcitonin gene-related peptide receptor antagonist for Alzheimer's disease

2020 ◽  
Vol 168 ◽  
pp. 108017
Author(s):  
Hana Na ◽  
Qini Gan ◽  
Liam Mcparland ◽  
Jack B. Yang ◽  
Hongbo Yao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Receptor Antagonist ◽  
Calcitonin Gene Related Peptide ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene

Refolding and Characterization of a Soluble Ectodomain Complex of the Calcitonin Gene-Related Peptide Receptor

Biochemistry ◽  
2010 ◽  
Vol 49 (9) ◽  
pp. 1862-1872 ◽  
Author(s):  
Christopher M. Koth ◽  
Norzehan Abdul-Manan ◽  
Christopher A. Lepre ◽  
Peter J. Connolly ◽  
Sanghee Yoo ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene

Calcitonin gene related peptide relaxes cholecystokinin-induced contraction in guinea pig gallbladder strips in vitro

1992 ◽  
Vol 70 (12) ◽  
pp. 1571-1575 ◽  
Author(s):  
L. W. Kline ◽  
P. K. T. Pang
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Calcitonin Gene Related Peptide ◽  
Intestinal Smooth Muscle ◽  
Human Calcitonin ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Dose Dependent

Calcitonin gene related peptide has been shown to relax vascular and intestinal smooth muscle. This study examines the effects of calcitonin gene related peptide on cholecystokinin-induced contraction of guinea pig gallbladder strips in vitro. Calcitonin gene related peptide was found to cause a dose-dependent relaxation of cholecystokinin-induced tension, which was blocked by the calcitonin gene related peptide receptor antagonist human calcitonin gene related peptide8–37. Previous studies demonstrated that calcitonin gene related peptide acted directly on guinea pig gallbladder smooth muscle to inhibit acetylcholine- or KCl-induced contraction. The present results further confirm that calcitonin gene related peptide acts directly on the smooth muscle. In addition, the use of L-NG-nitroarginine methyl ester, glibenclamide, and other agents strongly suggests that calcitonin gene related peptide also acts by way of the nonadrenergic noncholinergic nervous system, to induce the relaxation of cholecystokinin-induced contraction observed in the guinea pig gallbladder strips.Key words: calcitonin gene related peptide, gallbladder, cholecystokinin.

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