scholarly journals Difference in calcium dependency of insulin, glucagon and somatostatin secretion in response to glibenclamide in perfused rat pancreas

Diabetologia ◽  
1982 ◽  
Vol 22 (6) ◽  
pp. 475-479 ◽  
Author(s):  
S. Efendić ◽  
V. Grill ◽  
A. Nylén ◽  
C.-G. Östensson
Keyword(s):  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Calcium Dependency ◽  
Somatostatin Secretion

Glucose-induced somatostatin secretion by the rat pancreas is not potentiated by glucose

1984 ◽  
Vol 105 (4) ◽  
pp. 534-538 ◽  
Author(s):  
P. P. G. Gerber ◽  
E. R. Trimble ◽  
L. Herberg ◽  
A. E. Renold
Keyword(s):  
Insulin Secretion ◽  
Diabetic Rats ◽  
Glucose Stimulation ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Somatostatin Secretion ◽  
D Cell ◽  
D Cells ◽  
Cell Inhibition ◽  
Second Period

Abstract. The effect of previous exposure to glucose on subsequent glucose-stimulated insulin and somatostatin secretion has been investigated using the isolated perfused rat pancreas. As expected, when the pancreases of non-diabetic rats were exposed to 16.7 mM glucose on two occasions, 20 min apart, insulin secretion during the second period of exposure to high glucose was greater than that during the first period. By contrast, there was no potentiation of somatostatin secretion during the second glucose stimulation with respect to that of the first. Indeed, when the basal glucose concentration was low (1.4 or 2.8 mm) somatostatin secretion during the second glucose stimulation was lower than that during the first. Since exogenous insulin is known to inhibit glucoseinduced somatostatin secretion, it seemed possible that lack of visible potentiation of glucose-induced somatostatin secretion by glucose could have been due to partial D cell inhibition by simultaneously augmented insulin secretion during the second glucose stimulation. In an attempt to exclude such an interaction between B and D cells, somatostatin secretion was also studied in the pancreases of spontaneously diabetic, Wistar (BB) rats (these animals are insulin deficient and are maintained by daily injections of insulin). However, even though insulin secretion was not detectable from these pancreases, glucose potentiation of glucose-induced somatostatin secretion did not occur. Although the pancreatic B and D cells are known to respond in a similar manner to many secretagogues the present results show that glucose potentiation of glucosestimulated somatostatin secretion is not found under circumstances where potentiation of insulin secretion does occur. In addition, the absence of potentiated somatostatin secretion could not be attributed to partial inhibition of the D cell by insulin.

scholarly journals Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats. A study with the isolated perfused rat pancreas in vitro

Diabetologia ◽  
1992 ◽  
Vol 35 (11) ◽  
pp. 1035-1041 ◽  
Author(s):  
T. Kurose ◽  
K. Tsuda ◽  
H. Ishida ◽  
K. Tsuji ◽  
Y. Okamoto ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Neural Activation ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Somatostatin Secretion

Inhibition of insulin and somatostatin secretion and stimulation of glucagon release by homologous galanin in perfused rat pancreas

Diabetes ◽  
1990 ◽  
Vol 39 (8) ◽  
pp. 996-1001 ◽  
Author(s):  
P. Miralles ◽  
E. Peiro ◽  
P. Degano ◽  
R. A. Silvestre ◽  
J. Marco
Keyword(s):  
Glucagon Release ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Somatostatin Secretion ◽  
Stimulation Of

Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas

2009 ◽  
Vol 152 (1-3) ◽  
pp. 61-66 ◽  
Author(s):  
Eva M. Egido ◽  
Raquel Hernández ◽  
José Marco ◽  
Ramona A. Silvestre
Keyword(s):  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Somatostatin Secretion

Effects of Imidazoline Derivative RX871024 on Insulin, Glucagon, and Somatostatin Secretion from Isolated Perfused Rat Pancreas

1998 ◽  
Vol 252 (1) ◽  
pp. 162-165 ◽  
Author(s):  
I.B. Efanova ◽  
S.V. Zaitsev ◽  
A.M. Efanov ◽  
C.-G. Östenson ◽  
A. Raap ◽  
...  
Keyword(s):  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Somatostatin Secretion ◽  
Imidazoline Derivative

Multiple Effects of Leucine on Glue agon, Insulin, and Somatostatin Secretion from the Perfused Rat Pancreas*

Endocrinology ◽  
1985 ◽  
Vol 116 (3) ◽  
pp. 1168-1174 ◽  
Author(s):  
V. LECLERCQ-MEYER ◽  
J. MARCHAND ◽  
M. C. WOUSSEN-COLLE ◽  
M.-H. GIROIX ◽  
W. J. MALAISSE
Keyword(s):  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Somatostatin Secretion

Inhibition of Insulin and Somatostatin Secretion and Stimulation of Glucagon Release by Homologous Galanin in Perfused Rat Pancreas

Diabetes ◽  
1990 ◽  
Vol 39 (8) ◽  
pp. 996-1001 ◽  
Author(s):  
P. Miralles ◽  
E. Peiro ◽  
P. Degano ◽  
R. A. Silvestre ◽  
J. Marco
Keyword(s):  
Glucagon Release ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Somatostatin Secretion ◽  
Stimulation Of

scholarly journals Effect of Insulin on Glucose- and Arginine-Stimulated Somatostatin Secretion from the Isolated Perfused Rat Pancreas*

Endocrinology ◽  
1981 ◽  
Vol 109 (1) ◽  
pp. 279-283 ◽  
Author(s):  
PIETRO P. G. GERBER ◽  
ELISABETH R. TRIMBLE ◽  
CLAES B. WOLLHEIM ◽  
ALBERT E. RENOLD
Keyword(s):  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Somatostatin Secretion

Effect of enterostatin on insulin, glucagon, and somatostatin secretion in the perfused rat pancreas

Diabetes ◽  
1996 ◽  
Vol 45 (9) ◽  
pp. 1157-1160 ◽  
Author(s):  
R. A. Silvestre ◽  
J. Rodriguez-Gallardo ◽  
J. Marco
Keyword(s):  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Somatostatin Secretion
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