Anterior Cruciate Ligament Reconstructed Patients Who Recovered Normal Postural Control Have Dissimilar Brain Activation Patterns Compared to Healthy Controls

Postural control, which is a fundamental functional skill, reflects integration and coordination of sensory information. Damaged anterior cruciate ligament (ACL) may alter neural activation patterns in the brain, despite patients’ surgical reconstruction (ACLR). However, it is unknown whether ACLR patients with normal postural control have persistent neural adaptation in the brain. Therefore, we explored theta (4–8 Hz) and alpha-2 (10–12 Hz) oscillation bands at the prefrontal, premotor/supplementary motor, primary motor, somatosensory, and primary visual cortices, in which electrocortical activation is highly associated with goal-directed decision-making, preparation of movement, motor output, sensory input, and visual processing, respectively, during first 3 s of a single-leg stance at two different task complexities (stable/unstable) between ACLR patients and healthy controls. We observed that ACLR patients showed similar postural control ability to healthy controls, but dissimilar neural activation patterns in the brain. To conclude, we demonstrated that ACLR patients may rely on more neural sources on movement preparation in conjunction with sensory feedback during the early single-leg stance period relative to healthy controls to maintain postural control. This may be a compensatory protective mechanism to accommodate for the altered sensory inputs from the reconstructed knee and task complexity. Our study elucidates the strategically different brain activity utilized by ACLR patients to sustain postural control.

Implication of Electrophysiological Biomarkers in Psychosis: Focusing on Diagnosis and Treatment Response

Precision medicine has been considered a promising approach to diagnosis, treatment, and various interventions, considering the individual clinical and biological characteristics. Recent advances in biomarker development hold promise for guiding a new era of precision medicine style trials for psychiatric illnesses, including psychosis. Electroencephalography (EEG) can directly measure the full spatiotemporal dynamics of neural activation associated with a wide variety of cognitive processes. This manuscript reviews three aspects: prediction of diagnosis, prognostic aspects of disease progression and outcome, and prediction of treatment response that might be helpful in understanding the current status of electrophysiological biomarkers in precision medicine for patients with psychosis. Although previous EEG analysis could not be a powerful method for the diagnosis of psychiatric illness, recent methodological advances have shown the possibility of classifying and detecting mental illness. Some event-related potentials, such as mismatch negativity, have been associated with neurocognition, functioning, and illness progression in schizophrenia. Resting state studies, sophisticated ERP measures, and machine-learning approaches could make technical progress and provide important knowledge regarding neurophysiology, disease progression, and treatment response in patients with schizophrenia. Identifying potential biomarkers for the diagnosis and treatment response in schizophrenia is the first step towards precision medicine.

Visualizing Risky Behaviors Induces a Stronger Neural Response in Brain Areas Responsible for Mental Imagery and Emotions Than Visualizing Neutral Behaviors

In the present study, we used a neuroimaging technique (fMRI) to test the prediction that visualizing risky behaviors induces a stronger neural response in brain areas responsible for emotions and mental imagery than visualizing neutral behaviors. We identified several brain regions that were activated when participants produced mental images of risky versus neutral behaviors and these regions overlap with brain areas engaged in visual mental imagery, speech imagery and movement imagery. We also found that producing mental images of risky behaviors, in contrast to neutral behaviors, increased neural activation in the insula – a region engaged in emotional processing. This finding is in line with previous results demonstrating that the insula is recruited by tasks involving induction of emotional recall/imagery. Finally, we observed an increased BOLD signal in the cingulate gyrus (mid-cingulate area), which is associated with reward-based decision making and monitoring of decision outcomes. In summary, we demonstrated that mental images of risky behaviors, compared to risk-free behaviors, increased neural activation in brain areas engaged in mental imagery processes, emotional processing and decision making. These findings imply that the evaluation of everyday risky situations may originate in visualizing the potential consequences of risk taking and may be driven by emotional responses that result from mental imagery.

Studying the Evolution of Neural Activation Patterns During Training of Feed-Forward ReLU Networks

The ability of deep neural networks to form powerful emergent representations of complex statistical patterns in data is as remarkable as imperfectly understood. For deep ReLU networks, these are encoded in the mixed discrete–continuous structure of linear weight matrices and non-linear binary activations. Our article develops a new technique for instrumenting such networks to efficiently record activation statistics, such as information content (entropy) and similarity of patterns, in real-world training runs. We then study the evolution of activation patterns during training for networks of different architecture using different training and initialization strategies. As a result, we see characteristic- and general-related as well as architecture-related behavioral patterns: in particular, most architectures form bottom-up structure, with the exception of highly tuned state-of-the-art architectures and methods (PyramidNet and FixUp), where layers appear to converge more simultaneously. We also observe intermediate dips in entropy in conventional CNNs that are not visible in residual networks. A reference implementation is provided under a free license1.

Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio

Previous studies targeting inter-individual differences in pain processing in migraine mainly focused on the perception of pain. Our main aim was to disentangle pain anticipation and perception using a classical fear conditioning task, and investigate how migraine frequency and pre-scan cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio as an index of neurobiological stress response would relate to neural activation in these two phases. Functional Magnetic Resonance Imaging (fMRI) data of 23 participants (18 females; mean age: 27.61± 5.36) with episodic migraine without aura were analysed. We found that migraine frequency was significantly associated with pain anticipation in brain regions comprising the midcingulate and caudate, whereas pre-scan cortisol-to DHEA-S ratio was related to pain perception in the pre-supplementary motor area (pre-SMA). Both results suggest exaggerated preparatory responses to pain or more general to stressors, which may contribute to the allostatic load caused by stressors and migraine attacks on the brain.

Empathy for others versus for one's child: Associations with mothers' brain activation during a social cognitive task and with their toddlers' functioning

Caregivers who are higher in dispositional empathy tend to have children with better developmental outcomes; however, few studies have considered the role of child-directed (i.e., “parental”) empathy, which may be relevant for the caregiver–child relationship. We hypothesized that mothers’ parental empathy during their child’s infancy will be a stronger predictor of their child’s social-emotional functioning as a toddler than will mothers’ dispositional empathy. We further explored whether parental and dispositional empathy have shared or distinct patterns of neural activation during a social-cognitive movie-watching task. In 118 mother–infant dyads, greater parental empathy assessed when infants were 6 months old was associated with more social-emotional competencies and fewer problems in the children one year later, even after adjusting for dispositional empathy. In contrast, dispositional empathy was not associated with child functioning when controlling for parental empathy. In a subset of 20 mothers, insula activation was positively associated with specific facets of both dispositional and parental empathy, whereas right temporoparietal junction activation was associated only with parental empathy. Thus, dispositional and parental empathy appear to be dissociable by both brain and behavioral metrics. Parental empathy may be a viable target for interventions, especially for toddlers at risk for developing social-emotional difficulties.

Expression of CRY2 Gene in the Brain Is Related to Human Navigation

Navigation is a complex cognitive process. CRY2 gene has been proposed to play an important role in navigation behaviors in various non-human animal species. Utilizing a recently developed neuroimaging-transcriptomics approach, the present study reported a tentative link between the CRY2 gene and human navigation. Specifically, we showed a significant pattern similarity between CRY2 gene expression in the human brain and navigation-related neural activation in functional magnetic resonance imaging. To further illuminate the functionality of CRY2 in human navigation, we examined the correlation between CRY2 expression and various cognitive processes underlying navigation, and found high correlation of CRY2 expression with neural activity of multiple cognitive domains, particularly object and shape perception and spatial memory. Further analyses on the relation between the neural activity of human navigation and the expression maps of genes of two CRY2-related pathways, i.e., the magnetoreceptive and circadian-related functions, found a trend of correlation for the CLOCK gene, a core circadian regulator gene, suggesting that CRY2 may modulate human navigation through its role in circadian rhythm. This observation was further confirmed by a behavioral study where individuals with better circadian regularity in daily life showed better sense of direction. Taken together, our study presents the first neural evidence that links CRY2 with human navigation, possibly through the modulation of circadian rhythm.

FAAH polymorphism (rs324420) modulates extinction recall in healthy humans: an fMRI study

Gold standard treatments for anxiety- and trauma-related disorders focus on exposure therapy promoting extinction learning and extinction retention. However, its efficacy is limited. Preclinical and particularly animal research has been able to demonstrate that homozygosity for the fatty acid amide hydrolase (FAAH) C385A allele, similar to FAAH inhibition, is associated with elevated concentrations of anandamide (AEA) and facilitates extinction learning and extinction recall. However, in humans, the underlying neurobiological processes are less well understood, and further knowledge might enhance the development of more effective therapies. In this functional magnetic resonance imaging (fMRI) study, a fear conditioning, fear extinction and extinction recall paradigm was conducted with 55 healthy male adults. They were genotyped for the FAAH single-nucleotide polymorphism (SNP) rs324420 to investigate differences related to extinction recall in neural activation and State–Trait Anxiety Inventory (STAI) ratings between AC heterozygotes and CC homozygotes (FAAH C385A SNP). Differential brain activation upon an unextinguished relative to an extinguished stimulus, was greater in AC heterozygotes as compared to CC homozygotes in core neural structures previously related to extinction recall, such as the medial superior frontal gyrus, the dorsal anterior cingulate and the anterior and middle insular cortex. Furthermore, AC heterozygotes displayed higher AEA levels and lower STAI-state ratings. Our data can be interpreted in line with previous suggestions of more successful extinction recall in A-allele carriers with elevated AEA levels. Data corroborate the hypothesis that the endocannabinoid system, particularly AEA, plays a modulatory role in the extinction of aversive memory.

Community-level racial prejudice potentiates Whites’ neural responses to out-group faces: A spatial meta-analytic approach

A persistent question in social neuroscience is whether the amygdala underlies racial prejudice. Despite decades of research, evidence for a stronger amygdala response to racial out-group versus in-group members has been mixed. Here, we consider a potential explanation for these conflicting results: that neural responses to racial out-group members vary systematically based on the level of racial prejudice of the surrounding community. To test this contextual sensitivity hypothesis, we conducted a spatial meta-analysis that included a comprehensive set of studies (n=22) examining neural responses to Black vs. White faces in primarily White participants. We evaluated whether community-level racial prejudice moderated neural activation to Black (vs. White) faces by aggregating individual explicit racial attitudes, obtained from Project Implicit, to the county in which each study was conducted. Multi-level kernel density analysis demonstrated that neural activation to Black (vs. White) faces was significantly higher in the right amygdala, dorsal anterior cingulate cortex, and dorsolateral prefrontal cortex in communities with higher (vs. lower) levels of racial prejudice. This same pattern of neural activation was not observed for income inequality or for the percentage of the population who was Black or college-educated, indicating specificity to community-level prejudice. Our findings highlight the potential utility of spatial meta-analyses for reconciling conflicting results in the social neuroscience literature by identifying features of the broader social context that may moderate neural responses to socially relevant stimuli.