Miglitol may have a blood glucose lowering effect unrelated to inhibition of alpha-glucosidase

1987 ◽  
Vol 31 (6) ◽  
pp. 723-724 ◽  
Author(s):  
P. H. Joubert ◽  
G. N. Foukaridis ◽  
M. L. Bopape
Keyword(s):  
Blood Glucose ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Glucose Lowering Effect ◽  
Alpha Glucosidase

scholarly journals Leptin contributes to the beneficial effects of insulin treatment in streptozotocin-diabetic male mice

2018 ◽  
Vol 315 (6) ◽  
pp. E1264-E1273
Author(s):  
Ursula H. Neumann ◽  
Michelle M. Kwon ◽  
Robert K. Baker ◽  
Timothy J. Kieffer
Keyword(s):  
Blood Glucose ◽  
Insulin Therapy ◽  
Daily Injection ◽  
Diabetic Mice ◽  
Glucose Lowering ◽  
Beneficial Effects ◽  
Glucose Levels ◽  
Lowering Effect ◽  
Blood Glucose Levels ◽  
Glucose Lowering Effect

It was long thought that the only hormone capable of reversing the catabolic consequences of diabetes was insulin. However, various studies have demonstrated that the adipocyte-derived hormone leptin can robustly lower blood glucose levels in rodent models of insulin-deficient diabetes. In addition, it has been suggested that some of the metabolic manifestations of insulin-deficient diabetes are due to hypoleptinemia as opposed to hypoinsulinemia. Because insulin therapy increases leptin levels, we sought to investigate the contribution of leptin to the beneficial effects of insulin therapy. To do this, we tested insulin therapy in streptozotocin (STZ) diabetic mice that were either on an ob/ ob background or that were given a leptin antagonist to determine if blocking leptin action would blunt the glucose-lowering effects of insulin therapy. We found that STZ diabetic ob/ ob mice have a diminished blood glucose-lowering effect in response to insulin therapy compared with STZ diabetic controls and exhibited more severe weight loss post-STZ injection. In addition, STZ diabetic mice administered a leptin antagonist through daily injection or plasmid expression respond less robustly to insulin therapy as assessed by both fasting blood glucose levels and blood glucose levels during an oral glucose tolerance test. However, leptin antagonism did not prevent the insulin-induced reduction in β-hydroxybutyrate and triglyceride levels. Therefore, we conclude that elevated leptin levels can contribute to the glucose-lowering effect of insulin therapy in insulin-deficient diabetes.

scholarly journals Aspirin potentiates blood glucose lowering effect of glimepiride-pioglitazone combination in streptozotocin-induced diabetic rats

2014 ◽  
Vol 46 (5) ◽  
pp. 562 ◽  
Author(s):  
Suvajit Das ◽  
Chiranjib Bagchi ◽  
SantanuKumar Tripathi ◽  
Soumita Bag
Keyword(s):  
Blood Glucose ◽  
Diabetic Rats ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Glucose Lowering Effect

Blood Glucose Lowering Effect and Safety of the Aqueous Leaf Extracts of Zanha africana

2015 ◽  
Vol 06 (09) ◽  
Author(s):  
Abdirahman YA Juma KK ◽  
Makori WA Agyirifo DS ◽  
Ngugi MP Gathumbi PK
Keyword(s):  
Blood Glucose ◽  
Leaf Extracts ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Glucose Lowering Effect

The Blood Glucose-lowering Effect of Racecadotril is not Attributable to Inhibition of Insulin-degrading Enzyme

2013 ◽  
Vol 46 (01) ◽  
pp. 73-74
Author(s):  
S. Kurklinsky ◽  
S. Abdul-Hay ◽  
M. McGuire ◽  
E. Howard ◽  
J. Knight ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Insulin Degrading Enzyme ◽  
Glucose Lowering ◽  
Degrading Enzyme ◽  
Lowering Effect ◽  
Glucose Lowering Effect

Blood glucose‐lowering effect of water and ethanolic extracts of Gynura procumbens (Lour.) Merr

2021 ◽  
Author(s):  
Cho L. Aung ◽  
Fumitaka Kawakami ◽  
Motoki Imai ◽  
Thet‐Thet Lwin ◽  
Makoto Kanzaki ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Effect Of Water ◽  
Ethanolic Extracts ◽  
Glucose Lowering Effect
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