Effect of inhibitors of prostaglandin synthesis on the furosemide action in the loop Henle of rat kidney

1988 ◽  
Vol 411 (5) ◽  
pp. 579-583 ◽  
Author(s):  
J. Greven ◽  
A. Farjam
1977 ◽  
Vol 28 (9) ◽  
pp. 992-997 ◽  
Author(s):  
Guillermo Valenzuela ◽  
H. Dudley Ross ◽  
Barrie J. Hodgson ◽  
Michael J.K. Harper ◽  
Carl J. Pauerstein

1990 ◽  
Vol 39 (4) ◽  
pp. 261-265 ◽  
Author(s):  
K.L. Liu ◽  
H.Hadi Aissa ◽  
M.C. Lareal ◽  
D. Benzoni ◽  
J. Sassard ◽  
...  

1982 ◽  
Vol 63 (s8) ◽  
pp. 235s-237s ◽  
Author(s):  
Carlos P. Vio ◽  
Laurie Churchill ◽  
Alicia Terragno ◽  
John C. McGiff ◽  
Norberto A. Terragno

1. The effect of arachidonic acid on kallikrein release was studied in an isolated rat kidney perfused with a modified Krebs-Henseleit solution. 2. Kallikrein activity was measured in both venous and urinary effluents, after DEAE-Sephadex chromatography with D-Val-Leu-Arg-p-nitroanilide as a substrate. 3. Arachidonic acid (AA) (30 nmol/ml) induced a threefold increase in kallikrein activity in the venous effluent (control = 131 ± 9 kallikrein amidase μ-units/ml vs AA = 411 ±49 kallikrein amidase μ-units/ml, P < 0.005). 4. The stimulatory effect of arachidonic acid on kallikrein release is mediated by prostaglandins, since it can be prevented by the addition of indomethacin (1 μg/ml). 5. Our results demonstrate that kallikrein is released by the perfused kidney into the renal venous effluent, and that this release can be hormonally regulated by a mechanism involving prostaglandin synthesis.


1983 ◽  
pp. 41-52 ◽  
Author(s):  
Josée Sraer ◽  
Wolfgang Siess ◽  
Fernand Dray ◽  
Raymond Ardaillou

Life Sciences ◽  
1981 ◽  
Vol 28 (12) ◽  
pp. 1381-1386
Author(s):  
Elizabeth S. Critser ◽  
Carol Ann Plumer ◽  
L.R. French

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