Stereochemistry and biological activity of the novel narcotic analgesic fenaridine

1989 ◽  
Vol 23 (5) ◽  
pp. 395-401
Author(s):  
R. S. Vartanyan ◽  
V. O. Martirosyan ◽  
S. A. Vartanyan ◽  
A. P. Engoyan ◽  
�. V. Vlasenko ◽  
...  
Keyword(s):  
Biological Activity ◽  
Narcotic Analgesic ◽  
The Novel

Chromanones with Leishmanicidal Activity from Calea uniflora

2007 ◽  
Vol 62 (5-6) ◽  
pp. 353-356 ◽  
Author(s):  
Andréa Mendes do Nascimento ◽  
Fernanda Cristina Costa ◽  
Otavio Henrique Thiemann ◽  
Dionéia Camilo Rodrigues de Oliveira
Keyword(s):  
Biological Activity ◽  
Growth Inhibition ◽  
Leishmania Major ◽  
Spectroscopic Methods ◽  
The Novel ◽  
Leishmanicidal Activity ◽  
Significant Growth ◽  
Significant Growth Inhibition

The dichloromethane extract of Calea uniflora afforded a mixture of two novel chromanones, uniflorol-A (1) and uniflorol-B (2), and one known chromanone, 2,2-dimethyl-6- (1-hydroxyethyl)-chroman-4-one (3). The structures of these compounds were determined by spectroscopic methods. Biological activity of the compounds against Leishmania major promastigotes was evaluated. Mixture of the novel chromanones 1 and 2 showed significant growth inhibition of the parasite in the micrograms per milliliter range.

scholarly journals Site-specific Structural Transformation of the Novel Antifungal Cycle Depsipeptide FR901469. Synthesis and Biological Activity of FR203903.

2001 ◽  
Vol 54 (2) ◽  
pp. 193-197 ◽  
Author(s):  
AKIRA TANAKA ◽  
DAVID BARRETT ◽  
AKIHIKO FUJIE ◽  
NOBUHARU SHIGEMATSU ◽  
MICHIZANE HASHIMOTO ◽  
...  
Keyword(s):  
Biological Activity ◽  
Structural Transformation ◽  
The Novel ◽  
Site Specific

scholarly journals SYNTHESIS, STRUCTURE, AND BIOLOGICAL ACTIVITY OF NOVEL BISPIDINE DERIVATIVES

2021 ◽  
pp. 69-74
Author(s):  
AIGUL YE. MALMAKOVA ◽  
VALENTINA K. YU ◽  
KALDYBAY D. PRALIYEV ◽  
ALTYNAI B. KALDYBAYEVA ◽  
MARZHAN K. AMIRKULOVA
Keyword(s):  
Biological Activity ◽  
Local Anesthetic ◽  
The Novel ◽  
Anesthetic Activity ◽  
Local Anesthetic Activity ◽  
Scientific Representations ◽  
Depth Study ◽  
Low Toxicity ◽  
Pharmacological Screening ◽  
Derivatives Of

Objective: Derivatives of 3,7-diazabicyclo[3.3.1]nonan-9-one attract considerable attention from pharmacists for the treatment of a wide rangeof diseases. According to this interest, the novel derivatives of 3-cyclopropanmethyl-7-alkoxyalkyl-3,7-diazabicyclo[3.3.1]nonan-9-one withisopropoxypropyl and ethoxypropyl substituents in the position 7 had been synthesized to study their biological activity and toxicity. The practicalsignificance of the work is in the accumulation and development of scientific representations about diazabicyclic compounds, methods for theirsynthesis, structure, and properties, which can subsequently be used in a targeted design and identification of even more complex systems, as wellas in the development of further research in the field of 3,7-diazabicyclo[3.3.1]nonanes. For this purpose, complexes of the synthesized compoundswith β-cyclodextrin are obtained and their biological activity is investigated at the Department of Pharmacology of S.D. Asfendiyarov Kazakh NationalMedical University with the aid of the pharmacological tests.Methods: An experimental study of local anesthetic activity on the models of infiltration, conduction anesthesia, and acute toxicity of synthesizedmolecules was carried out using primary screening methods.Results: As a result of pharmacological screening, it has been found that the compounds exhibit local anesthetic activity and low toxicity and wasrecommended for in-depth study of their pharmacological properties.Conclusion: It turned out that a nature of the N-alkoxyalkyl radical does not affect the toxicity of cyclopropanmethyl- substituted bispidines. In theseries of O-benzoyloximes of bispidinones, the isopropoxypropyl- substituted analog is 1.3 times less toxic than ethoxypropyl- one.

Characterization, tissue distribution and biological activity of the novel neuropeptide secretoneurin

Neuropeptides ◽  
1994 ◽  
Vol 26 ◽  
pp. 22
Author(s):  
R. Fischer-Colbrie ◽  
R. Kirchmair ◽  
J. Marksteiner ◽  
A. Saria ◽  
N. Reinisch ◽  
...  
Keyword(s):  
Biological Activity ◽  
Tissue Distribution ◽  
The Novel

scholarly journals The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity

2010 ◽  
Vol 20 (2) ◽  
pp. 210-219 ◽  
Author(s):  
Zrinka Rajić ◽  
Dimitra Hadjipavlou-Litina ◽  
Eleni Pontiki ◽  
Jan Balzarini ◽  
Branka Zorc
Keyword(s):  
Biological Activity ◽  
The Novel ◽  
Derivatives Of

Synthesis and Biological Activity of the Novel Adenosine Analogs; 3-Amino-6-(β-D-ribofuranosyl)pyrazolo[3,4-c]pyrazole and 3-Amino-1-methyl-6-(β-D-ribofuranosyl)pyrazolo[3,4-c]pyrazole

1994 ◽  
Vol 13 (1-3) ◽  
pp. 405-420 ◽  
Author(s):  
David A. Berry ◽  
Linda L. Wotring ◽  
John C. Drach ◽  
Leroy B. Townsend
Keyword(s):  
Biological Activity ◽  
The Novel ◽  
Adenosine Analogs

Engineering disulfide bonds of the novel human β-defensins hBD-27 and hBD-28: Differences in disulfide formation and biological activity among human β-defensins

Biopolymers ◽  
2004 ◽  
Vol 80 (1) ◽  
pp. 34-49 ◽  
Author(s):  
Axel Schulz ◽  
Enno Klüver ◽  
Sandra Schulz-Maronde ◽  
Knut Adermann
Keyword(s):  
Biological Activity ◽  
Disulfide Bonds ◽  
The Novel ◽  
Disulfide Formation

Synthesis and biological activity of the novel nitric oxide synthase inhibitor Nω′-hydroxy-Nω-methyl-L-arginine

1994 ◽  
pp. 769-771 ◽  
Author(s):  
Humphrey A. Moynihan ◽  
Stanley M. Roberts ◽  
Hazel Weldon ◽  
Graham H. Allcock ◽  
Erik E. Änggård ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biological Activity ◽  
Nitric Oxide Synthase ◽  
The Novel ◽  
Nitric Oxide Synthase Inhibitor ◽  
Synthase Inhibitor ◽  
Oxide Synthase
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