Treatment of nonsteroidal antiinflammatory drug-induced gastric ulcers with misoprostol

1992 ◽  
Vol 37 (12) ◽  
pp. 1820-1824 ◽  
Author(s):  
Richard Jaszewski ◽  
David Y. Graham ◽  
Scott C. Stromatt
Keyword(s):  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Gastric Ulcers ◽  
Drug Induced

Aging and Nonsteroidal Antiinflammatory Drug-Induced Renal Dysfunction

DICP ◽  
1989 ◽  
Vol 23 (1) ◽  
pp. 74-75
Author(s):  
Robert A. Blum ◽  
William A. Watson
Keyword(s):  
Renal Dysfunction ◽  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Drug Induced

Identification of nonsteroidal antiinflammatory drug-induced gastroduodenal injury in children with juvenile rheumatoid arthritis

1993 ◽  
Vol 122 (4) ◽  
pp. 647-649 ◽  
Author(s):  
Andrew E. Mulberg ◽  
Christine Linz ◽  
Elana Bern ◽  
Laurie Tucker ◽  
Menno Verhave ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Juvenile Rheumatoid Arthritis ◽  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Drug Induced

Effect of Antiulcer Drugs for Treatment of Nonsteroidal Antiinflammatory Drug-Induced Ulcers

2001 ◽  
pp. 215-218 ◽  
Author(s):  
Yuji Mizokami ◽  
Takahisa Shiraishi ◽  
Toshiya Otsubo ◽  
Yoshiyuki Kariya ◽  
Hiroshi Nakamura ◽  
...  
Keyword(s):  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Drug Induced ◽  
Antiulcer Drugs

Nonsteroidal antiinflammatory drug-induced colonic strictures: A case report

1991 ◽  
Vol 100 (4) ◽  
pp. 1119-1122 ◽  
Author(s):  
Thomas Huber ◽  
Charles Ruchti ◽  
Fred Halter
Keyword(s):  
Case Report ◽  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Drug Induced ◽  
Colonic Strictures

scholarly journals Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis

1999 ◽  
Vol 277 (5) ◽  
pp. E937-E947 ◽  
Author(s):  
Robin P. Boushey ◽  
Bernardo Yusta ◽  
Daniel J. Drucker
Keyword(s):  
Biological Effects ◽  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Myeloperoxidase Activity ◽  
Drug Induced ◽  
Mucosal Epithelium ◽  
Crypt Cell Proliferation ◽  
Glucagon Like Peptide ◽  
Complementary Actions

Glucagon-like peptides (GLPs) are secreted from enteroendocrine cells in the gastrointestinal tract. GLP-1 actions regulate blood glucose, whereas GLP-2 exerts trophic effects on intestinal mucosal epithelium. Although GLP-1 actions are preserved in diseases such as diabetes, GLP-2 action has not been extensively studied in the setting of intestinal disease. We have now evaluated the biological effects of a human GLP-2 analog in the setting of experimental murine nonsteroidal antiinflammatory drug-induced enteritis. Human (h)[Gly2]GLP-2 significantly improved survival whether administered before, concomitant with, or after indomethacin. h[Gly2]GLP-2-treated mice exhibited reduced histological evidence of disease activity, fewer intestinal ulcerations, and decreased myeloperoxidase activity in the small bowel ( P < 0.05, h[Gly2]GLP-2- vs. saline-treated controls). h[Gly2]GLP-2 significantly reduced cytokine induction, bacteremia, and the percentage of positive splenic and hepatic bacterial cultures ( P < 0.05). h[Gly2]GLP-2 enhanced epithelial proliferation ( P < 0.05 for increased crypt cell proliferation in h[Gly2]GLP-2- vs. saline-treated mice after indomethacin) and reduced apoptosis in the crypt compartment ( P < 0.02). These observations demonstrate that a human GLP-2 analog exerts multiple complementary actions that serve to preserve the integrity of the mucosal epithelium in experimental gastrointestinal injury in vivo.

Nonsteroidal Antiinflammatory Drug-Induced Pseudoporphyria: A Case Series

2002 ◽  
Vol 6 (4) ◽  
pp. 320-326 ◽  
Author(s):  
Jeffrey R. LaDuca ◽  
Peter H. Bouman ◽  
Anthony A. Gaspari
Keyword(s):  
Case Series ◽  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Drug Induced

Nonsteroidal antiinflammatory drug-induced colonic stricture

1995 ◽  
Vol 40 (2) ◽  
pp. 315-319 ◽  
Author(s):  
Michael H. E. Robinson ◽  
Timothy Wheatley ◽  
Ian H. Leach
Keyword(s):  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Colonic Stricture ◽  
Drug Induced
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