Normal mouse lung tissue produces a growth-inhibitory factor(s) preferential for mouse monocytic leukemia cells

1989 ◽  
Vol 30 (3) ◽  
pp. 139-144 ◽  
Author(s):  
Togo Ikuta ◽  
Yoshio Honma ◽  
Junko Okabe-Kado ◽  
Takashi Kasukabe ◽  
Motoo Hozumi
Keyword(s):  
Lung Tissue ◽  
Normal Mouse ◽  
Inhibitory Factor ◽  
Leukemia Cells ◽  
Mouse Lung ◽  
Monocytic Leukemia ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Mouse Lung Tissue

scholarly journals Could a Growth Inhibitory Factor, Present Only during Pregnancy, be Made Available to Treat Cancer in Adults? A Commentary

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Mizejewski GJ
Keyword(s):  
Fetal Growth ◽  
Therapeutic Agent ◽  
Germ Cell Tumors ◽  
Inhibitory Factor ◽  
Additional Function ◽  
Major Function ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Age Dependent ◽  
Growth Promoting

Human alpha-fetoprotein (AFP) is well-known as the “gold standard” biomarker for liver and germ cell tumors. It has also been utilized as a pregnancy screening analyte for neural tube defects as well as Down syndrome, when combined with other gestational-age dependent biomarkers. However, a lesser known and recognized property of AFP is its role in the maintenance and monitoring of fetal growth during ontogenetic development in man. Although a major function of AFP during pregnancy involves the serum transport of estrogens, fatty acids, retinoid, and other compounds, the positive and negative regulation of fetal growth is a vital additional function of AFP. Human AFP largely functions as a growth promoting agent; however, the fetal protein is able to temporarily convert to a growth inhibitory factor in stress and shock environments in the fetal milieu. The development of a transient form of AFP or its derived peptides could be harnessed for use as an adjunct therapeutic agent to treat cancer in adults.

scholarly journals Circular RNA profiles in mouse lung tissue induced by radon

2017 ◽  
Vol 22 (1) ◽  
Author(s):  
Weiwei Pei ◽  
Lijing Tao ◽  
Leshuai W. Zhang ◽  
Shuyu Zhang ◽  
Jianping Cao ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Circular Rna ◽  
Mouse Lung ◽  
Mouse Lung Tissue
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