Loss of Growth Inhibitory Factor in Degenerative Disease

1995 ◽  
pp. 621-624
Author(s):  
Yoko Uchida ◽  
Naruhito Otsuka ◽  
Yasuo Ihara
Keyword(s):  
Degenerative Disease ◽  
Inhibitory Factor ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory

scholarly journals Could a Growth Inhibitory Factor, Present Only during Pregnancy, be Made Available to Treat Cancer in Adults? A Commentary

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Mizejewski GJ
Keyword(s):  
Fetal Growth ◽  
Therapeutic Agent ◽  
Germ Cell Tumors ◽  
Inhibitory Factor ◽  
Additional Function ◽  
Major Function ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Age Dependent ◽  
Growth Promoting

Human alpha-fetoprotein (AFP) is well-known as the “gold standard” biomarker for liver and germ cell tumors. It has also been utilized as a pregnancy screening analyte for neural tube defects as well as Down syndrome, when combined with other gestational-age dependent biomarkers. However, a lesser known and recognized property of AFP is its role in the maintenance and monitoring of fetal growth during ontogenetic development in man. Although a major function of AFP during pregnancy involves the serum transport of estrogens, fatty acids, retinoid, and other compounds, the positive and negative regulation of fetal growth is a vital additional function of AFP. Human AFP largely functions as a growth promoting agent; however, the fetal protein is able to temporarily convert to a growth inhibitory factor in stress and shock environments in the fetal milieu. The development of a transient form of AFP or its derived peptides could be harnessed for use as an adjunct therapeutic agent to treat cancer in adults.

Normal mouse lung tissue produces a growth-inhibitory factor(s) preferential for mouse monocytic leukemia cells

1989 ◽  
Vol 30 (3) ◽  
pp. 139-144 ◽  
Author(s):  
Togo Ikuta ◽  
Yoshio Honma ◽  
Junko Okabe-Kado ◽  
Takashi Kasukabe ◽  
Motoo Hozumi
Keyword(s):  
Lung Tissue ◽  
Normal Mouse ◽  
Inhibitory Factor ◽  
Leukemia Cells ◽  
Mouse Lung ◽  
Monocytic Leukemia ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Mouse Lung Tissue

Evidence for the production of a growth-inhibitory factor by human granulosa-luteal cells

1993 ◽  
Vol 36 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Liliana B. Dain ◽  
Miguel A. Bley ◽  
José L. Barañao ◽  
Marta Tesone
Keyword(s):  
Inhibitory Factor ◽  
Luteal Cells ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory
Sign in / Sign up

Export Citation Format

Share Document