Five days of erythromycin estolate versus ten days of penicillin V in the treatment of group a streptococcal tonsillopharyngitis in children

The clinical pharmacology of orally administered antibiotics was investigated in 106 infants and children. The antibiotic suspensions studied were ampicillin, cephalexin, erythromycin estolate, erythromycin ethylsuccinate, penicillin G, and penicillin V. The feeding status of the patients was evaluated in relation to the concentrations of drugs in serum, saliva, and tears. Peak concentrations and area-under-the-curve values of cephalexin, penicillin V, and penicillin G were reduced 40% to 60% in patients given milk and drug concurrently. Absorption was enhanced when erythromycin ethylsuccinate was given with milk. After administration of both erythromycin formulations, penicillin V and ampicillin, salivary concentrations exceeded the minimal inhibitory concentrations for most pneumococci and group A streptococci and for many meningococci. The clinical implications of these pharmacokinetic data are discussed.

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In Vitro Effect on Group A Streptococci of Loracarbef versus Cefadroxil, Cefaclor and Penicillin V

Scandinavian Journal of Infectious Diseases ◽

10.3109/00365549309169667 ◽

1993 ◽

Vol 25 (1) ◽

pp. 37-42

Author(s):

Carl Kamme ◽

Ann-Cathrine Petersson

Keyword(s):

Group A Streptococci ◽

Penicillin V ◽

Group A ◽

Vitro Effect

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ERYTHROMYCIN PROPIONATE AND POTASSIUM PENICILLIN V IN THE TREATMENT OF GROUP A STREPTOCOCCAL PHARYNGITIS

PEDIATRICS ◽

10.1542/peds.31.1.22 ◽

1963 ◽

Vol 31 (1) ◽

pp. 22-28

Author(s):

Maxwell Stillerman ◽

Stanley H. Bernstein ◽

Martha Smith ◽

Jack D. Gorvoy

Keyword(s):

Relative Effectiveness ◽

Streptococcal Pharyngitis ◽

Group A Streptococci ◽

Cure Rate ◽

Acute Pharyngitis ◽

Penicillin V ◽

Daily Dose ◽

Group A ◽

Potassium Penicillin

The relative effectiveness of erythromycin propionate and K penicillin V in two dosage schedules was evaluated in the treatment of 261 cases of acute pharyngitis from which Group A hemolytic streptococci were recovered from December, 1958, to June, 1959. Erythromycin propionate, in a daily dose of 30 mg/kg up to 1.0 gm, and K penicillin V, in daily doses of 375 mg and 750 mg, were administered orally for 10 days. The adjusted bacterial cure rate was 78% among 86 patients treated with erythromycin, 72% among 102 patients treated with K penicillin V, 375 mg, and 88% among 73 patients treated with K penicillin V, 750 mg. The data indicate that K penicillin V was more effective in eradicating Group A streptococci from the pharynx in a daily dose of 750 mg than 375 mg, and suggest that erythromycin propionate in the dosage used, was less effective than K penicillin V, 750 mg, but equally as effective as K penicillin V, 375 mg daily. The incidence, time of occurrence, and results of retreatments of bacterial relapses are presented, and two possible causes of relapses are considered.

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Comparative efficacy and safety of 3-day azithromycin and 10-day penicillin V treatment of group A beta-hemolytic streptococcal pharyngitis in children.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.40.4.1005 ◽

1996 ◽

Vol 40 (4) ◽

pp. 1005-1008 ◽

Cited By ~ 49

Author(s):

L Pacifico ◽

F Scopetti ◽

A Ranucci ◽

M Pataracchia ◽

F Savignoni ◽

...

Keyword(s):

Clinical Success ◽

Streptococcal Pharyngitis ◽

Efficacy And Safety ◽

Comparative Efficacy ◽

Once Daily ◽

Penicillin V ◽

Oral Regimen ◽

Beta Hemolytic Streptococcus ◽

Group A

The efficacy and safety of a 3-day course of azithromycin oral suspension (10 mg/kg of body weight once daily) were compared with those of penicillin V (50,000 U/kg/day in two divided doses) in children aged 3 to 12 years for the treatment of symptomatic pharyngitis caused by the group A beta-hemolytic streptococcus (GABHS). For the 154 evaluable patients, the original infecting strain of GABHS was eliminated at the end of follow-up (34 to 36 days after treatment started) from 67 (85.8%) of 78 penicillin-treated patients and 41 (53.9%) of 76 azithromycin-treated patients (P < 0.0001). Overall clinical success was achieved in 71 (91.0%) of 78 penicillin V-treated patients and 57 (75.0%) of 76 azithromycin-treated patients (P < 0.05). Potential drug-related adverse events were reported for 5.5 and 8.6% of the penicillin V- and azithromycin-treated patients, respectively (P = 0.6). In the present study, a once-daily (10 mg/kg), 3-day oral regimen of azithromycin was as safe as a 10-day course of penicillin but did not represent an effective alternative to penicillin for the treatment of GABHS pharyngitis, even for those children with azithromycin-susceptible strains.

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