clinical implications
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2022 ◽  
Vol 29 (1) ◽  
pp. 1-46
Author(s):  
Nazanin Andalibi ◽  
Ashley Lacombe-Duncan ◽  
Lee Roosevelt ◽  
Kylie Wojciechowski ◽  
Cameron Giniel

Navigating conception, pregnancy, and loss is challenging for lesbian, gay, bisexual, transgender, and queer (LGBTQ) people, who experience stigma due to LGBTQ identity, other identities (e.g., loss), and intersections thereof. We conducted interviews with 17 LGBTQ people with recent pregnancy loss experiences. Taking LGBTQ identity and loss as a starting point, we used an intracategorical intersectional lens to uncover the benefits and challenges of LGBTQ-specific and non-LGBTQ-specific pregnancy and loss-related online spaces. Participants used LGBTQ-specific online spaces to enact individual, interpersonal, and collective resilience. However, those with multiple marginalized identities (e.g., people of color and non-partnered individuals), faced barriers in finding support within LGBTQ-specific spaces compared to those holding privileged identities (e.g., White and married). Non-LGBTQ spaces were beneficial for some informational needs, but not community and emotional needs due to pervasive heteronormativity, cisnormativity, and a perceived need to educate. We conceptualize experiences of exclusion as symbolic annihilation and intersectional invisibility, and discuss clinical implications and design directions.


2022 ◽  
Vol 146 ◽  
pp. 112503
Author(s):  
Justin Zeien ◽  
Wendy Qiu ◽  
Mason Triay ◽  
Hemangini A. Dhaibar ◽  
Diana Cruz-Topete ◽  
...  

Author(s):  
Giorgia Dalpiaz ◽  
Lorenzo Gamberini ◽  
Aldo Carnevale ◽  
Savino Spadaro ◽  
Carlo Alberto Mazzoli ◽  
...  

2022 ◽  
pp. 1-6
Author(s):  
Dingkai Xu ◽  
Ling Wang

Pituitary adenomas (PAs) account for the top three primary intracranial tumors in terms of total incidence rate. PAs can cause severe endocrine disorders and even malignant features, such as invasion, metastasis, and recurrence. Therefore, the early diagnosis and accurate prognosis would be greatly beneficial for clinical treatment of PAs. MicroRNAs (miRNAs) are small, protein-noncoding RNAs that regulate gene expression posttranscriptionally. They regulate essential physiological processes, including proliferation, growth, and apoptosis, and also they involve in the invasion and metastasis of malignant tumors. At the tissue level, differential miRNA expression in endocrine malignancies including PAs has been reported. When miRNAs have been successfully detected in various biofluids and cell-free environments, their important roles as potential screening or prognostic biomarkers have been extensively investigated. The current work reviews recent studies on the emerging roles of miRNAs in PAs and the clinical significance.


Cureus ◽  
2022 ◽  
Author(s):  
Leonardo P Suciadi ◽  
Joshua Henrina ◽  
Iwan Cahyo Santosa Putra ◽  
Irvan Cahyadi ◽  
Hoo Felicia Hadi Gunawan

2022 ◽  
Vol 8 ◽  
Author(s):  
Julie Niemann Holm-Jacobsen ◽  
Caspar Bundgaard-Nielsen ◽  
Louise Søndergaard Rold ◽  
Ann-Maria Jensen ◽  
Shakil Shakar ◽  
...  

Background: SARS-CoV-2 has resulted in a global pandemic since its outbreak in Wuhan, 2019. Virus transmission primarily occurs through close contact, respiratory droplets, and aerosol particles. However, since SARS-CoV-2 has been detected in fecal and rectal samples from infected individuals, the fecal-oral route has been suggested as another potential route of transmission. This study aimed to investigate the prevalence and clinical implications of rectal SARS-CoV-2 shedding in Danish COVID-19 patients.Methods: Hospitalized and non-hospitalized adults and children who were recently tested with a pharyngeal COVID-19 test, were included in the study. A rectal swab was collected from all participants. Hospitalized adults and COVID-19 positive children were followed with both pharyngeal and rectal swabs until two consecutive negative results were obtained. RT-qPCR targeting the envelope gene was used to detect SARS-CoV-2 in the samples. Demographic, medical, and biochemical information was obtained through questionnaires and medical records.Results: Twenty-eight of 52 (53.8%) COVID-19 positive adults and children were positive for SARS-CoV-2 in rectal swabs. Seven of the rectal positive participants were followed for more than 6 days. Two of these (28.6%) continued to test positive in their rectal swabs for up to 29 days after the pharyngeal swabs had turned negative. Hospitalized rectal positive and rectal negative adults were comparable regarding demographic, medical, and biochemical information. Furthermore, no difference was observed in the severity of the disease among the two groups.Conclusions: We provided evidence of rectal SARS-CoV-2 shedding in Danish COVID-19 patients. The clinical importance of rectal SARS-CoV-2 shedding appears to be minimal.


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